Receptor retinoinske kiseline beta

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Receptor retinoinske kiseline, beta
PDB slika je bazirana na 1xap.
Dostupne strukture
1dsz, 1hra, 1xap, 1xdk
Identifikatori
Simboli RARB; HAP; NR1B2; RRB2
Vanjski ID OMIM180220 MGI97857 HomoloGene68100 GeneCards: RARB Gene
Pregled RNK izražavanja
PBB GE RARB 205080 at tn.png
PBB GE RARB 208530 s at tn.png
PBB GE RARB 208412 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5915 218772
Ensembl ENSG00000077092 ENSMUSG00000017491
UniProt P10826 Q8K1P6
RefSeq (mRNA) NM_000965 NM_011243
RefSeq (protein) NP_000956 NP_035373
Lokacija (UCSC) Chr 3:
25.19 - 25.61 Mb
Chr 14:
15.22 - 15.61 Mb
PubMed pretraga [1] [2]

Receptor retinoinske kiseline beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor encoded by the RARB gene.[1]

Ovaj gen kodira receptor retinoinske kiseline beta, koji je član tiroid-steroid hormon receptorske super-familije nuklearnih transkripcionih regulatora. Ovaj receptor je lokalizovan u citoplazmi i u sub-nuklearnim kompartmanima. On vezuje retinoinsku kiselinu, biološki aktivnu formu vitamina A čime posreduje ćelijsku signalizaciju embrionske morfogene, ćelijski rast i diferencijaciju. Smatra se da ovaj protein ograničava rast mnogih ćelijskih tipova putem regulacije izražavanja gena. Ovaj gen je prvo identifikovan kod hepatocelularnih karcinoma, kod kojih se on nalazi pored integracionog mesta hepatitis B virusa. Ovaj gen izražava najmanje dve transkriptne varijante; jedan dodatni transkript je bio opisan, ali puna dužina njegovog proteina nije bila određena.[1]

Interakcije[уреди]

Pokazano je da receptor retinoinske kiseline beta ima interakciju sa Nuklearni receptor srodnim 1 proteinom.[2]

Reference[уреди]

  1. 1,0 1,1 „Entrez Gene: RARB retinoic acid receptor, beta”. 
  2. ^ Perlmann, T; L, Jansson (1995). „A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1”. Genes Dev. UNITED STATES. 9 (7): 769—82. ISSN 0890-9369. PMID 7705655. 

Literatura[уреди]

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  • O, Klein; Y, Grignon; T, Civit; et al. (2006). „[Methylation status of RARbeta gene promoter in low and high grade cerebral glioma. Comparison with normal tissue. Immuno-histochemical study of nuclear RARbeta expression in low and high grade cerebral glioma cells. Comparison with normal cells. 48 tumors]”. Neuro-Chirurgie. 51 (3-4 Pt 1): 147—54. PMID 16389900. 
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  • de Thé H; Vivanco-Ruiz MM; P, Tiollais; et al. (1990). „Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene.”. Nature. 343 (6254): 177—80. PMID 2153268. doi:10.1038/343177a0. 
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  • de Thé H, Marchio A, Tiollais P, Dejean A (1988). „A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma.”. Nature. 330 (6149): 667—70. PMID 2825037. doi:10.1038/330667a0. 
  • N, Brand; M, Petkovich; A, Krust; et al. (1988). „Identification of a second human retinoic acid receptor.”. Nature. 332 (6167): 850—3. PMID 2833708. doi:10.1038/332850a0. 
  • Benbrook D, Lernhardt E, Pfahl M (1988). „A new retinoic acid receptor identified from a hepatocellular carcinoma.”. Nature. 333 (6174): 669—72. PMID 2836738. doi:10.1038/333669a0. 
  • MG, Mattei; de Thé H; JF, Mattei; et al. (1988). „Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3.”. Hum. Genet. 80 (2): 189—90. PMID 2844650. doi:10.1007/BF00702867. 
  • Dejean A, Bougueleret L, Grzeschik KH, Tiollais P (1986). „Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma.”. Nature. 322 (6074): 70—2. PMID 3014347. doi:10.1038/322070a0. 
  • Si SP, Tsou HC, Lee X, Peacocke M (1995). „Effect of cellular senescence and retinoic acid on the expression of cellular retinoic acid binding proteins in skin fibroblasts.”. Exp. Cell Res. 219 (1): 243—8. PMID 7628539. doi:10.1006/excr.1995.1224. 
  • B, Houle; M, Pelletier; J, Wu; et al. (1994). „Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines.”. Cancer Res. 54 (2): 365—9. PMID 8275470. 
  • RM, Knegtel; M, Katahira; JG, Schilthuis; et al. (1993). „The solution structure of the human retinoic acid receptor-beta DNA-binding domain.”. J. Biomol. NMR. 3 (1): 1—17. PMID 8383553. doi:10.1007/BF00242472. 

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