TRNK (karboksimetiluridin34-5-O)-metiltransferaza
| TRNK (karboksimetiluridin34-5-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.229 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK (karboksimetiluridin34-5-O)-metiltransferaza (EC 2.1.1.229, ALKBH8, ABH8, Trm9, tRNK metiltransferaza 9) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (karboksimetiluridin34-5-O)-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + karboksimetiluridin34 u tRNK S-adenozil-L-homocistein + 5-(2-metoksi-2-oksoetil)uridin34 u tRNK
Ovaj enzim katalizuje posttranslacionu modifikaciju uridinskih ostataka u pokretnoj poziciji 34 antikodonske petlje tRNK.
Reference[уреди | уреди извор]
- ^ Fu, D., Brophy, J.A., Chan, C.T., Atmore, K.A., Begley, U., Paules, R.S., Dedon, P.C., Begley, T.J. and Samson, L.D. (2010). „Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival”. Mol. Cell Biol. 30: 2449—2459. PMID 20308323.
- ^ Songe-Møller, L., van den Born, E., Leihne, V., Vågbø, C.B., Kristoffersen, T., Krokan, H.E., Kirpekar, F., Falnes, P.Ø. and Klungland, A. (2010). „Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding”. Mol. Cell Biol. 30: 1814—1827. PMID 20123966.
- ^ Kalhor, H.R. & Clarke, S. (2003). „Novel methyltransferase for modified uridine residues at the wobble position of tRNA”. Mol. Cell Biol. 23: 9283—9292. PMID 14645538.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- TRNA+(carboxymethyluridine34-5-O)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
