ORC6
| Kompleks prepoznavanja mesta početka, podjedinica 6 (ORC6) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| Simbol | ORC6 | ||||||||
| Pfam | PF05460 | ||||||||
| InterPro | IPR008721 | ||||||||
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Kompleks prepoznavanja mesta početka, podjedinica 6 je protein koji je kod ljudi kodiran ORC6 genom.
Ovaj gen je podjedinica ORC kompleksa. Pokazano je da su ORC6 i ORC1 labavo povezani sa sržnim kompleskom koji sarži ORC2. Studije genskog blokiranja dejstvom male interferirajuće RNK su pokazale da ovaj protein ima esencijalnu ulogu u koordinaciji hromozomske replikacije segregacije[1][2].
Reference[uredi | uredi izvor]
- ^ Dhar SK, Dutta A (novembar 2000). „Identification and characterization of the human ORC6 homolog”. J Biol Chem. 275 (45): 34983—8. PMID 10945994. doi:10.1074/jbc.M006069200.
- ^ „Entrez Gene: ORC6L origin recognition complex, subunit 6 like (yeast)”.
Literatura[uredi | uredi izvor]
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- Jiang W, McDonald D, Hope TJ, Hunter T (1999). „Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication”. EMBO J. 18 (20): 5703—13. PMC 1171637
. PMID 10523313. doi:10.1093/emboj/18.20.5703. - Hartley JL, Temple GF, Brasch MA (2001). „DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788—95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
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- Chesnokov I, Remus D, Botchan M (2001). „Functional analysis of mutant and wild-type Drosophila origin recognition complex”. Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11997—2002. PMC 59756 . PMID 11593009. doi:10.1073/pnas.211342798.
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- Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
- Ramachandran N; Hainsworth E; Bhullar B; et al. (2004). „Self-assembling protein microarrays”. Science. 305 (5680): 86—90. PMID 15232106. doi:10.1126/science.1097639.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Wiemann S; Arlt D; Huber W; et al. (2004). „From ORFeome to biology: a functional genomics pipeline”. Genome Res. 14 (10B): 2136—44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
- Sibani S, Price GB, Zannis-Hadjopoulos M (2005). „Ku80 binds to human replication origins prior to the assembly of the ORC complex”. Biochemistry. 44 (21): 7885—96. PMID 15910003. doi:10.1021/bi047327n.
- Mehrle A; Rosenfelder H; Schupp I; et al. (2006). „The LIFEdb database in 2006”. Nucleic Acids Res. 34 (Database issue): D415—8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
- Olsen JV; Blagoev B; Gnad F; et al. (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635—48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
