Proliferatini ćelijski nuklearni antigen

С Википедије, слободне енциклопедије
Proliferating cell nuclear antigen
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Spoljašnji IDGeneCards: [1]
Obrazac RNK izražavanja
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Proliferativni ćelijski nuklearni antigen (PCNA) je DNK stega koja deluje kao faktor procesivnosti za DNK polimerazu δ u eukariotskim ćelijama i koja je esencijalna za replikaciju. PCNA je homotrimer koji ostvaruje svoju procesivnost putem obuhvatanja DNK, pri čemu ona deluje kao osnova na kojoj se vezuju drugi proteini koji su neophodni za DNK replikaciju, DNK popravku, remodelovanje hromatina i epigenetiku.[1]

Mnogi proteini formiraju interakcije sa dva poznata PCNA-interagujuća motiva: PCNA interagujuća peptidna (PIP) kutija[2] i AlkB homolog 2 PCNA interagujući motiv (APIM).[3] Proteinsko vezivanje za PCNA putem PIP-kutije se uglavnom ostvaruje tokom DNK replikacije, dok su proteini koji se vezuju za PCNA putem APIM prvenstveno važni u kontekstu genotoksičnog stresa.[4]

U responsu na DNK oštećenje, ovaj protein biva ubikvitinisan i učestvuje u putu RAD6 zavisne DNK popravke. Poznate su dve transkriptne varijante koje kodiraju isti protein. Pseudogeni ovog gena su prisutni na hromozomu 4 i na X hromozomu.[5]

Interakcije[уреди | уреди извор]

PCNA formira interakcije sa:

Proteini koji formiraju interakcije sa PCNA preko APIM obuhvataju ljudski AlkB homolog 2, TFIIS-L, TFII-I, Rad51B,[3] XPA,[69] ZRANB3,[70] i FBH1.[71]

Reference[уреди | уреди извор]

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