23С рРНК (аденин2085-Н6)-диметилтрансфераза
| 23S rRNK (adenin2085-N6)-dimetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.184 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
23S rRNK (adenin2085-N6)-dimetiltransferaza (EC 2.1.1.184, ErmC' metiltransferaza, ermC metilaza, ermC 23S rRNK metiltransferaza, rRNK:m6A metiltransferaza ErmC' , ErmC' , rRNK metiltransferaza ErmC' ) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (adenin2085-N6)-dimetiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 S-adenozil-L-metionin + adenin2085 u 23S rRNK 2 S-adenozil-L-homocistein + N6-dimetiladenin2085 u 23S rRNK
ErmC je metiltransferaza koja pruža otpornost na makrolid-linkozamid-streptograminsku B grupu antibiotika tako što katalizuje metilaciju 23S rRNK na adeninu2085.
Reference
[уреди | уреди извор]- ^ Zhong, P., Pratt, S.D., Edalji, R.P., Walter, K.A., Holzman, T.F., Shivakumar, A.G. and Katz, L. (1995). „Substrate requirements for ErmC′ methyltransferase activity”. J. Bacteriol. 177: 4327—4332. PMID 7543473.
- ^ Denoya, C. & Dubnau, D. (1989). „Mono- and dimethylating activities and kinetic studies of the ermC 23 S rRNA methyltransferase”. J. Biol. Chem. 264: 2615—2624. PMID 2492520.
- ^ Denoya, C.D. & Dubnau, D. (1987). „Site and substrate specificity of the ermC 23S rRNA methyltransferase”. J. Bacteriol. 169: 3857—3860. PMID 2440853.
- ^ Bussiere, D.E., Muchmore, S.W., Dealwis, C.G., Schluckebier, G., Nienaber, V.L., Edalji, R.P., Walter, K.A., Ladror, U.S., Holzman, T.F. and Abad-Zapatero, C. (1998). „Crystal structure of ErmC′, an rRNA methyltransferase which mediates antibiotic resistance in bacteria”. Biochemistry. 37: 7103—7112. PMID 9585521.
- ^ Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J. and Abad-Zapatero, C. (1999). „The 2.2 Å structure of the rRNA methyltransferase ErmC′ and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism”. J. Mol. Biol. 289: 277—291. PMID 10366505.
- ^ Maravic, G., Bujnicki, J.M., Feder, M., Pongor, S. and Flogel, M. (2003). „Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC′ redefines the substrate-binding site and suggests a model for protein-RNA interactions”. Nucleic Acids Res. 31: 4941—4949. PMID 12907737.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- 23S+rRNA+(adenine2085-N6)-dimethyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
