Бета-пептидилна аминопептидаза
| Beta-peptidilna aminopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.25 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Beta-peptidilna aminopeptidaza (EC 3.4.11.25, BapA) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Oslobađanje N-terminalne beta-homoamino kiseline sa peptida koji se sastoje od 2 do 6 aminokiselina
Sphingosinicella xenopeptidilytica vrsta 3-2W4 može da koristi beta-peptide beta-homoVal-beta-homoAla-beta-homoLeu i beta-homoAla-beta-homoLeu kao jedini izvor ugljenika i energije.
Reference
[уреди | уреди извор]- ^ Heck, T., Limbach, M., Geueke, B., Zacharias, M., Gardiner, J., Kohler, H.P. and Seebach, D. (2006). „Enzymatic degradation of β- and mixed α,β-oligopeptides”. Chem. Biodivers. 3: 1325—1348. PMID 17193247.
- ^ Geueke, B., Namoto, K., Seebach, D. and Kohler, H.P. (2005). „A novel β-peptidyl aminopeptidase (BapA) from strain 3-2W4 cleaves peptide bonds of synthetic β-tri- and β-dipeptides”. J. Bacteriol. 187: 5910—5917. PMID 16109932.
- ^ Geueke, B., Heck, T., Limbach, M., Nesatyy, V., Seebach, D. and Kohler, H.P. (2006). „Bacterial β-peptidyl aminopeptidases with unique substrate specificities for β-oligopeptides and mixed β,α-oligopeptides”. FEBS J. 273: 5261—5272. PMID 17064315.
- ^ Heck, T., Kohler, H.P., Limbach, M., Flögel, O., Seebach, D. and Geueke, B. (2007). „Enzyme-catalyzed formation of β-peptides: β-peptidyl aminopeptidases BapA and DmpA acting as β-peptide-synthesizing enzymes”. Chem. Biodivers. 4: 2016—1030. PMID 17886858.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Beta-peptidyl+aminopeptidase на US National Library of Medicine Medical Subject Headings (MeSH)
