Метиламин-кориноид протеин Цо-метилтрансфераза
| Metilamin-korinoid protein Co-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.248 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Metilamin-korinoid protein Co-metiltransferaza (EC 2.1.1.248, mtmB (gen), monometilaminska metiltransferaza) je enzim sa sistematskim imenom monometilamin:5-hidroksibenzimidazolilkobamid Co-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- metilamin + [Co(I) metilamin-specifični korinoidni protein] [metil-Co(III) metilamin-specifični korinoidni protein] + amonijak
Enzim koji katalizuje transfer metil grupa sa metilamina na metilamin-specifični korinoidni protein (MtmC), učestvuje u metanogenezi. Ovaj enzim sadrži neobičnu aminokiselinu pirolizin.
Reference
[уреди | уреди извор]- ^ Burke, S.A. & Krzycki, J.A. (1997). „Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri”. J. Biol. Chem. 272: 16570—16577. PMID 9195968.
- ^ Burke, S.A., Lo, S.L. and Krzycki, J.A. (1998). „Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine”. J. Bacteriol. 180: 3432—3440. PMID 9642198.
- ^ Krzycki, J.A. (2004). „Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases”. Curr. Opin. Chem. Biol. 8: 484—491. PMID 15450490.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Methylamine---corrinoid+protein+Co-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
