Питрилизин
| Pitrilizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.55 | ||||||||
| CAS broj | 81611-78-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Pitrilizin (EC 3.4.24.55, Escherichia coli proteaza III, proteaza Pi, proteinaza Pi, PTR, Escherichia coli metaloproteinaza Pi) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Preferentno razlaganje -Tyr16-Leu- i -Phe25-Tyr- veza oksidovanog lanca insulina B. Takođe deluje na druge supstrate sa masom manjom od 7 kDa, kao što su insulin i glukagon
Ovaj enzim je prisutan u bakteriji Escherichia coli.
Reference[уреди | уреди извор]
- ^ Finch, P.W., Wilson, R.E., Brown, K., Hickson, I.D. and Emmerson, P.T. (1986). „Complete nucleotide sequence of the Escherichia coli ptr gene encoding protease III”. Nucleic Acids Res. 14: 7695—7703. PMID 3534791.
- ^ Affholter, J.A., Fried, V.A. and Roth, R.A. (1988). „Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III”. Science. 242: 1415—1418. PMID 3059494.
- ^ Becker, A.B. & Roth, R.A. (1992). „An unusual active site identified in a family of zinc metalloendopeptidases”. Proc. Natl. Acad. Sci. USA. 89: 3835—3839. PMID 1570301.
- ^ Ding, L., Becker, A.B., Suzuki, A. and Roth, R.A. (1992). „Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III”. J. Biol. Chem. 267: 2414—2420. PMID 1733942.
- ^ Anastasi, A., Knight, C.G. and Barrett, A.J. (1993). „Characterization of the bacterial metalloendopeptidase pitrilysin by use of a continuous fluorescence assay”. Biochem. J. 290: 601—607. PMID 7680857.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Pitrilysin на US National Library of Medicine Medical Subject Headings (MeSH)
