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Arsenat reduktaza (glutaredoksin)

С Википедије, слободне енциклопедије
Arsenat reduktaza (glutaredoksin)
Identifikatori
EC broj1.20.4.1
CAS broj146907-46-2
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Arsenat reduktaza (glutaredoksin) (EC 1.20.4.1, Arsenate reductase (glutaredoxin)) je enzim sa sistematskim imenom glutaredoksin:arsenat oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

arsenat + glutaredoksin arsenit + glutaredoksin disulfid + H2O

Ovaj enzim je molibdoenzim.

  1. ^ Gladysheva, T., Liu, J.Y. and Rosen, B.P. (1996). „His-8 lowers the pKa of the essential Cys-12 residue of the ArsC arsenate reductase of plasmid R773”. J. Biol. Chem. 271: 33256—33260. PMID 8969183. 
  2. ^ Gladysheva, T.B., Oden, K.L. and Rosen, B.P. (1994). „Properties of the arsenate reductase of plasmid R773”. Biochemistry. 33: 7288—7293. PMID 8003492. 
  3. ^ Holmgren, A. & Aslund, F. (1995). „Glutaredoxin”. Methods Enzymol. 252: 283—292. PMID 7476363. 
  4. ^ Ji, G.Y., Garber, E.A.E., Armes, L.G., Chen, C.M., Fuchs, J.A. and Silver, S. (1994). „Arsenate reductase of Staphylococcus aureus' plasmid PI258”. Biochemistry. 33: 7294—7299. 
  5. ^ Krafft, T. & Macy, J.M. (1998). „Purification and characterization of the respiratory arsenate reductase of Chrysiogenes arsenatis”. Eur. J. Biochem. 255: 647—653. PMID 9738904. 
  6. ^ Martin, J.L. (1995). „Thioredoxin - a fold for all reasons”. Structure. 3: 245—250. PMID 7788290. 
  7. ^ Messens, J., Hayburn, G., Desmyter, A., Laus, G. and Wyns, L. (1999). „The essential catalytic redox couple in arsenate reductase from Staphylococcus aureus'”. Biochemistry. 38: 16857—16865. PMID 10606519. 
  8. ^ Radabaugh, T.R. & Aposhian, H.V. (2000). „Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase”. Chem. Res. Toxicol. 13: 26—30. PMID 10649963. 
  9. ^ Sato, T. & Kobayashi, Y. (1998). „The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite”. J. Bacteriol. 180: 1655—1661. PMID 9537360. 
  10. ^ Shi, J., Vlamis-Gardikas, V., Aslund, F., Holmgren, A. and Rosen, B.P. (1999). „Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction”. J. Biol. Chem. 274: 36039—36042. PMID 10593884. 

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