Arsenat reduktaza (glutaredoksin)

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Arsenat reduktaza (glutaredoksin)
EC broj
CAS broj 146907-46-2
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Arsenat reduktaza (glutaredoksin) (EC, Arsenate reductase (glutaredoxin)) je enzim sa sistematskim imenom glutaredoksin:arsenat oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

arsenat + glutaredoksin arsenit + glutaredoksin disulfid + H2O

Ovaj enzim je molibdoenzim.


  1. Gladysheva, T., Liu, J.Y. and Rosen, B.P. (1996). „His-8 lowers the pKa of the essential Cys-12 residue of the ArsC arsenate reductase of plasmid R773”. J. Biol. Chem. 271: 33256—33260. PMID 8969183. 
  2. Gladysheva, T.B., Oden, K.L. and Rosen, B.P. (1994). „Properties of the arsenate reductase of plasmid R773”. Biochemistry. 33: 7288—7293. PMID 8003492. 
  3. Holmgren, A. and Aslund, F. (1995). „Glutaredoxin”. Methods Enzymol. 252: 283—292. PMID 7476363. 
  4. Ji, G.Y., Garber, E.A.E., Armes, L.G., Chen, C.M., Fuchs, J.A. and Silver, S. (1994). „Arsenate reductase of Staphylococcus aureus' plasmid PI258”. Biochemistry. 33: 7294—7299. 
  5. Krafft, T. and Macy, J.M. (1998). „Purification and characterization of the respiratory arsenate reductase of Chrysiogenes arsenatis”. Eur. J. Biochem. 255: 647—653. PMID 9738904. 
  6. Martin, J.L. (1995). „Thioredoxin - a fold for all reasons”. Structure. 3: 245—250. PMID 7788290. 
  7. Messens, J., Hayburn, G., Desmyter, A., Laus, G. and Wyns, L. (1999). „The essential catalytic redox couple in arsenate reductase from Staphylococcus aureus'”. Biochemistry. 38: 16857—16865. PMID 10606519. 
  8. Radabaugh, T.R. and Aposhian, H.V. (2000). „Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase”. Chem. Res. Toxicol. 13: 26—30. PMID 10649963. 
  9. Sato, T. and Kobayashi, Y. (1998). „The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite”. J. Bacteriol. 180: 1655—1661. PMID 9537360. 
  10. Shi, J., Vlamis-Gardikas, V., Aslund, F., Holmgren, A. and Rosen, B.P. (1999). „Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction”. J. Biol. Chem. 274: 36039—36042. PMID 10593884. 


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