Arsenat reduktaza (glutaredoksin)

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Arsenat reduktaza (glutaredoksin)
Identifikatori
EC broj 1.20.4.1
CAS broj 146907-46-2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Arsenat reduktaza (glutaredoksin) (EC 1.20.4.1, Arsenate reductase (glutaredoxin)) je enzim sa sistematskim imenom glutaredoksin:arsenat oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

arsenat + glutaredoksin \rightleftharpoons arsenit + glutaredoksin disulfid + H2O

Ovaj enzim je molibdoenzim.

Reference[уреди]

  1. Gladysheva, T., Liu, J.Y. and Rosen, B.P. (1996). „His-8 lowers the pKa of the essential Cys-12 residue of the ArsC arsenate reductase of plasmid R773“. J. Biol. Chem. 271: 33256-33260. PMID 8969183. 
  2. Gladysheva, T.B., Oden, K.L. and Rosen, B.P. (1994). „Properties of the arsenate reductase of plasmid R773“. Biochemistry 33: 7288-7293. PMID 8003492. 
  3. Holmgren, A. and Aslund, F. (1995). „Glutaredoxin“. Methods Enzymol. 252: 283-292. PMID 7476363. 
  4. Ji, G.Y., Garber, E.A.E., Armes, L.G., Chen, C.M., Fuchs, J.A. and Silver, S. (1994). „Arsenate reductase of Staphylococcus aureus' plasmid PI258“. Biochemistry 33: 7294-7299. 
  5. Krafft, T. and Macy, J.M. (1998). „Purification and characterization of the respiratory arsenate reductase of Chrysiogenes arsenatis“. Eur. J. Biochem. 255: 647-653. PMID 9738904. 
  6. Martin, J.L. (1995). „Thioredoxin - a fold for all reasons“. Structure 3: 245-250. PMID 7788290. 
  7. Messens, J., Hayburn, G., Desmyter, A., Laus, G. and Wyns, L. (1999). „The essential catalytic redox couple in arsenate reductase from Staphylococcus aureus'“. Biochemistry 38: 16857-16865. PMID 10606519. 
  8. Radabaugh, T.R. and Aposhian, H.V. (2000). „Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase“. Chem. Res. Toxicol. 13: 26-30. PMID 10649963. 
  9. Sato, T. and Kobayashi, Y. (1998). „The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite“. J. Bacteriol. 180: 1655-1661. PMID 9537360. 
  10. Shi, J., Vlamis-Gardikas, V., Aslund, F., Holmgren, A. and Rosen, B.P. (1999). „Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction“. J. Biol. Chem. 274: 36039-36042. PMID 10593884. 

Literatura[уреди]

Spoljašnje vezе[уреди]