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Dalteparin natrijum

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Dalteparin natrijum
Klinički podaci
Prodajno imeBoxol, Eurodal, Fragmin, Ligoframin
Drugs.comsodium.html Monografija
Način primeneParenteralno
Farmakokinetički podaci
Poluvreme eliminacije2 h
IzlučivanjeUrinom
Identifikatori
CAS broj9041-08-1 ДаY
ATC kodB01AB04 (WHO)
DrugBankDB06779 ДаY

Dalteparin natrijum je heparin niske molekulske težine (LMWH) pripremljen degradacijom azotastom kiselinom nefrakcionisanog heparina iz svinjske stomačne sluzokože. On je antikoagulans. On se sastoji od jako kiselih sulfatiranih polisaharidnih lanaca sa prosećnom molekulskom težinom od 5000 i oko 90% materijala u opsegu 2000-9000. LMWH ima predvidljiviji respons, dužu bioraspoloživost, i duži anti-Xa poluživot od nefrakcionisanog heparina. Dalteparin se može bezbedno koristiti kod trudnih žena.[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]

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  2. ^ Bell WR, Royall RM: Heparin-associated thrombocytopenia: a comparison of three heparin preparations. N Engl J Med. 1980 Oct 16;303(16):902-7. PMID 6997743
  3. ^ Ockelford PA, Patterson J, Johns AS: A double-blind randomized placebo controlled trial of thromboprophylaxis in major elective general surgery using once daily injections of a low molecular weight heparin fragment (Fragmin). Thromb Haemost. 1989 Dec 29;62(4):1046-9. PMID 2559484
  4. ^ Hartl P, Brucke P, Dienstl E, Vinazzer H: Prophylaxis of thromboembolism in general surgery: comparison between standard heparin and Fragmin. Thromb Res. 1990 Feb 15;57(4):577-84. PMID 2158151
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  7. ^ Malm K, Dahlback B, Arnljots B: Low-molecular-weight heparin (dalteparin) effectively prevents thrombosis in a rat model of deep arterial injury. Plast Reconstr Surg. 2003 Apr 15;111(5):1659-66. PMID 12655212
  8. ^ Tincani E, Mannucci C, Casolari B, Turrini F, Crowther MA, Prisco D, Cenci AM, Bondi M: Safety of dalteparin for the prophylaxis of venous thromboembolism in elderly medical patients with renal insufficiency: a pilot study. Haematologica. 2006 Jul;91(7):976-9. Epub 2006 Jun 1. PMID 16757417
  9. ^ Schmid P, Brodmann D, Fischer AG, Wuillemin WA: Study of bioaccumulation of dalteparin at a prophylactic dose in patients with various degrees of impaired renal function. J Thromb Haemost. 2009 Apr;7(4):552-8. Epub 2009 Jan 19. PMID 19175499
  10. ^ Abe W, Ikejima K, Lang T, Okumura K, Enomoto N, Kitamura T, Takei Y, Sato N: Low molecular weight heparin prevents hepatic fibrogenesis caused by carbon tetrachloride in the rat. J Hepatol. 2007 Feb;46(2):286-94. Epub 2006 Oct 25. PMID 17166617
  11. ^ Frydman A: Low-molecular-weight heparins: an overview of their pharmacodynamics, pharmacokinetics and metabolism in humans. Haemostasis. 1996;26 Suppl 2:24-38. PMID 8707165
  12. ^ Samama MM, Gerotziafas GT: Comparative pharmacokinetics of LMWHs. Semin Thromb Hemost. 2000;26 Suppl 1:31-8. PMID 11011804
  13. ^ Rey E, Rivard GE: Prophylaxis and treatment of thromboembolic diseases during pregnancy with dalteparin. Int J Gynaecol Obstet. 2000 Oct;71(1):19-24. PMID 11044537
  14. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
  15. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958.  уреди

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