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Tropomiozinska receptorska kinaza C

С Википедије, слободне енциклопедије
NTRK3
Available structures
PDBPretraga ortologa: PDBe RCSB
Identifikatori
AlijasiNTRK3
Spoljašnji IDOMIM: 191316 MGI: 97385 HomoloGene: 49183 GeneCards: NTRK3
Obrazac RNK izražavanja




More reference expression data
Ortolozi
VrsteČovekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008746
NM_182809

RefSeq (protein)

NP_032772
NP_877961

Location (UCSC)n/aChr 7: 78.18 – 78.74 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor NT-3 faktora rasta (neurotrono tirozinsko kinazni receptor tip 3, TrkC tirozinska kinaza, Trk-C receptor) protein protein je koji je kod ljudi kodiran NTRK3 genom.[4]

TrkC je katalitički receptor sa visokim afinitetom za neurotrofin NT-3 (neurotrofin-3). Kao takav, TrkC posreduje višestruke efekte ovog neurotrofnog faktora, među kojima je neuronska diferencijacija i opstanak.

TrkC receptor je deo velike familije receptorskih tirozinskih kinaza. "Tirozinske kinaze" su enzimi koji imaju sposobnost dodavanja fosfatne grupe na pojedine tirozine na ciljnim proteinima, ili "supstratima". Receptorske tirozinske kinaze su "tirozinske kinaze kojesu locirane na ćelijskim membranama, i koje se aktiviraju vezivanjem liganda za njihove ekstracelularne domene.

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000059146 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ McGregor LM, Baylin SB, Griffin CA, Hawkins AL, Nelkin BD (1994). „Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant”. Genomics. 22 (2): 267—72. PMID 7806211. doi:10.1006/geno.1994.1383. 
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  • Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). „A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma”. Nature Genetics. 18 (2): 184—7. PMID 9462753. doi:10.1038/ng0298-184. 
  • Urfer R, Tsoulfas P, O'Connell L, Hongo JA, Zhao W, Presta LG (1998). „High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors”. The Journal of Biological Chemistry. 273 (10): 5829—40. PMID 9488719. doi:10.1074/jbc.273.10.5829. 
  • Hu YQ, Koo PH (1998). „Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin”. Journal of Neurochemistry. 71 (1): 213—20. PMID 9648868. doi:10.1046/j.1471-4159.1998.71010213.x. 
  • Ichaso N, Rodriguez RE, Martin-Zanca D, Gonzalez-Sarmiento R (1998). „Genomic characterization of the human trkC gene”. Oncogene. 17 (14): 1871—5. PMID 9778053. doi:10.1038/sj.onc.1202100. 
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