3-Heksuloza-6-fosfatna sintaza

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3-Heksuloza-6-fosfatna sintaza
Identifikatori
EC broj 4.1.2.43
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

3-Heksuloza-6-fosfatna sintaza (EC 4.1.2.43, D-arabino-3-heksuloza 6-fosfat formaldehid-lijaza, 3-heksulozafosfat sintaza, 3-heksuloza fosfat sintaza, HPS) je enzim sa sistematskim imenom D-arabino-heks-3-uloza-6-fosfat formaldehid-lijaza (formira D-ribuloza-5-fosfat).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-arabino-heks-3-uloza 6-fosfat \rightleftharpoons D-ribuloza 5-fosfat + formaldehid

Za maksimalno dejstvo ovog enzima je neophodan jon Mg2+ ili Mn2+.

Reference[уреди]

  1. Ferenci, T., Strøm, T. and Quayle, J.R. (1974). „Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus”. Biochem. J. 144: 477-486. PMID 4219834. 
  2. Kato, N., Ohashi, H., Tani, Y. and Ogata, K. (1978). „3-Hexulosephosphate synthase from Methylomonas aminofaciens 77a. Purification, properties and kinetics”. Biochim. Biophys. Acta 523: 236-244. PMID 564713. 
  3. Yanase, H., Ikeyama, K., Mitsui, R., Ra, S., Kita, K., Sakai, Y. and Kato, N. (1996). „Cloning and sequence analysis of the gene encoding 3-hexulose-6-phosphate synthase from the methylotrophic bacterium, Methylomonas aminofaciens 77a, and its expression in Escherichia coli”. FEMS Microbiol. Lett. 135: 201-205. PMID 8595859. 
  4. Yurimoto, H., Kato, N. and Sakai, Y. (2005). „Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism”. Chem. Rec. 5: 367-375. PMID 16278835. 
  5. Kato, N., Yurimoto, H. and Thauer, R.K. (2006). „The physiological role of the ribulose monophosphate pathway in bacteria and archaea”. Biosci. Biotechnol. Biochem. 70: 10-21. PMID 16428816. 
  6. Orita, I., Yurimoto, H., Hirai, R., Kawarabayasi, Y., Sakai, Y. and Kato, N. (2005). „The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway”. J. Bacteriol. 187: 3636-3642. PMID 15901685. 
  7. Kato, N., Miyamoto, N., Shimao, M. and Sakazawa, C. (1988). „3-Hexulose phosphate pynthase from a new facultative methylotroph, Mycobacterium gastri MB19”. Agric. Biol. Chem. 52: 2659-2661. 

Literatura[уреди]

Spoljašnje veze[уреди]