3-Heksuloza-6-fosfatna sintaza

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3-Heksuloza-6-fosfatna sintaza
Identifikatori
EC broj 4.1.2.43
Baze podataka
IntEnz IntEnz pregled
BRENDA BRENDA pristup
ExPASy NiceZyme pregled
KEGG KEGG pristup
MetaCyc metabolički put
PRIAM profil
Strukture PBP RCSB PDB PDBe PDBsum

3-Heksuloza-6-fosfatna sintaza (EC 4.1.2.43, D-arabino-3-heksuloza 6-fosfat formaldehid-lijaza, 3-heksulozafosfat sintaza, 3-heksuloza fosfat sintaza, HPS) je enzim sa sistematskim imenom D-arabino-heks-3-uloza-6-fosfat formaldehid-lijaza (formira D-ribuloza-5-fosfat).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-arabino-heks-3-uloza 6-fosfat D-ribuloza 5-fosfat + formaldehid

Za maksimalno dejstvo ovog enzima je neophodan jon Mg2+ ili Mn2+.

Reference[уреди]

  1. Ferenci, T., Strøm, T. and Quayle, J.R. (1974). „Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus”. Biochem. J. 144: 477—486. PMID 4219834. 
  2. Kato, N., Ohashi, H., Tani, Y. and Ogata, K. (1978). „3-Hexulosephosphate synthase from Methylomonas aminofaciens 77a. Purification, properties and kinetics”. Biochim. Biophys. Acta. 523: 236—244. PMID 564713. 
  3. Yanase, H., Ikeyama, K., Mitsui, R., Ra, S., Kita, K., Sakai, Y. and Kato, N. (1996). „Cloning and sequence analysis of the gene encoding 3-hexulose-6-phosphate synthase from the methylotrophic bacterium, Methylomonas aminofaciens 77a, and its expression in Escherichia coli”. FEMS Microbiol. Lett. 135: 201—205. PMID 8595859. 
  4. Yurimoto, H., Kato, N. and Sakai, Y. (2005). „Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism”. Chem. Rec. 5: 367—375. PMID 16278835. 
  5. Kato, N., Yurimoto, H. and Thauer, R.K. (2006). „The physiological role of the ribulose monophosphate pathway in bacteria and archaea”. Biosci. Biotechnol. Biochem. 70: 10—21. PMID 16428816. 
  6. Orita, I., Yurimoto, H., Hirai, R., Kawarabayasi, Y., Sakai, Y. and Kato, N. (2005). „The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway”. J. Bacteriol. 187: 3636—3642. PMID 15901685. 
  7. Kato, N., Miyamoto, N., Shimao, M. and Sakazawa, C. (1988). „3-Hexulose phosphate pynthase from a new facultative methylotroph, Mycobacterium gastri MB19”. Agric. Biol. Chem. 52: 2659—2661. 

Literatura[уреди]

Spoljašnje veze[уреди]