Adinazolam

Adinazolam
Klinički podaci
Drugs.com	Monografija
Farmakokinetički podaci
Poluvreme eliminacije	3 h
Identifikatori
CAS broj	37115-32-5
ATC kod	N05BA07 (WHO)
PubChem	CID 37632
DrugBank	DB00546
ChemSpider	34519
ChEBI	CHEBI:251412
ChEMBL	CHEMBL328250
Hemijski podaci
Formula	C19H18ClN5
Molarna masa	351,833
	SMILES CN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N12; ;
	InChI InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3 ; Key:GJSLOMWRLALDCT-UHFFFAOYSA-N ;

Adinazolam je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 351,833 Da.^[1]^[2]^[3]^[4]^[5]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	4
Broj donora vodonika	0
Broj rotacionih veza	3
Particioni koeficijent^[6] (ALogP)	3,5
Rastvorljivost^[7] (logS, log(mol/L))	-5,6
Polarna površina^[8] (PSA, Å²)	46,3

Reference

^ Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. Lahti, R. A.; Sethy, V. H.; Barsuhn, C.; Hester, J. B. (новембар 1983). „Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine”. Neuropharmacology. 22 (11): 1277—82. PMID 6320036. doi:10.1016/0028-3908(83)90200-9.
^ Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. Sethy, V. H.; Collins, R. J.; Daniels, E. G. (август 1984). „Determination of biological activity of adinazolam and its metabolites”. J Pharm Pharmacol. 36 (8): 546—8. PMID 6148400. doi:10.1111/j.2042-7158.1984.tb04449.x.
^ File SE, Pellow S: Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites. Neurosci Lett. 1985 Oct 24;61(1-2):115-9. File, S. E.; Pellow, S. (1985). „Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites”. Neuroscience Letters. 61 (1–2): 115—119. PMID 2867497. doi:10.1016/0304-3940(85)90410-0.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Adinazolam

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. Lahti, R. A.; Sethy, V. H.; Barsuhn, C.; Hester, J. B. (новембар 1983). „Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine”. Neuropharmacology. 22 (11): 1277—82. PMID 6320036. doi:10.1016/0028-3908(83)90200-9.

[2] Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. Sethy, V. H.; Collins, R. J.; Daniels, E. G. (август 1984). „Determination of biological activity of adinazolam and its metabolites”. J Pharm Pharmacol. 36 (8): 546—8. PMID 6148400. doi:10.1111/j.2042-7158.1984.tb04449.x.

[3] File SE, Pellow S: Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites. Neurosci Lett. 1985 Oct 24;61(1-2):115-9. File, S. E.; Pellow, S. (1985). „Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites”. Neuroscience Letters. 61 (1–2): 115—119. PMID 2867497. doi:10.1016/0304-3940(85)90410-0.

[4] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[6] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[7] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[8] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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