Amineptin

Amineptin
Klinički podaci
Prodajno ime	Maneon, Survector
Drugs.com	Monografija
Farmakokinetički podaci
Poluvreme eliminacije	48 minuta
Identifikatori
CAS broj	57574-09-1
ATC kod	N06AA19 (WHO)
PubChem	CID 34869
DrugBank	DB04836
ChemSpider	32090
ChEBI	CHEBI:32499
ChEMBL	CHEMBL418995
Hemijski podaci
Formula	C22H28ClNO2
Molarna masa	373,916
	SMILES [Cl-].OC(=O)CCCCCC[NH2+]C1C2=CC=CC=C2CCC2=CC=CC=C12; ;
	InChI InChI=1S/C22H27NO2.ClH/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);1H ; Key:VDPUXONTAVMIKZ-UHFFFAOYSA-N ;

Amineptin je organsko jedinjenje, koje sadrži 22 atoma ugljenika i ima molekulsku masu od 373,916 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	2
Broj rotacionih veza	8
Particioni koeficijent^[8] (ALogP)	1,1
Rastvorljivost^[9] (logS, log(mol/L))	-7,0
Polarna površina^[10] (PSA, Å²)	92,4

Reference

^ Vaugeois JM, Corera AT, Deslandes A, Costentin J: Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor. Pharmacol Biochem Behav. Vaugeois, J. M.; Corera, A. T.; Deslandes, A.; Costentin, J. (јун 1999). „Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor”. Pharmacology, Biochemistry, and Behavior. 63 (2): 285—90. PMID 10371658. doi:10.1016/s0091-3057(98)00242-1.
^ Grupper C: [New iatrogenic acne: acne caused by amineptin (Survector)] Ann Dermatol Venereol. 1988;Grupper, C. (1988). „New iatrogenic acne: Acne caused by amineptin (Survector)”. Annales de Dermatologie et de Venereologie. 115 (11): 1174—6. PMID 2977079.
^ Thioly-Bensoussan D, Charpentier A, Triller R, Thioly F, Blanchet P, Tricoire N, Noury JY, Grupper C: [Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases] Ann Dermatol Venereol. 1988;Thioly-Bensoussan, D.; Charpentier, A.; Triller, R.; Thioly, F.; Blanchet, P.; Tricoire, N.; Noury, J. Y.; Grupper, C. (1988). „Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases”. Annales de Dermatologie et de Venereologie. 115 (11): 1177—80. PMID 2977080.
^ Vexiau P, Gourmel B, Husson C, Castot A, Rybojad M, Julien R, Fiet J, Puissant A, Cathelineau G: [Severe lesions of acne type induced by chronic amineptin poisoning: apropos of 6 cases] Ann Dermatol Venereol. 1988;Vexiau, P.; Gourmel, B.; Husson, C.; Castot, A.; Rybojad, M.; Julien, R.; Fiet, J.; Puissant, A.; Cathelineau, G. (1988). „Severe lesions of acne type induced by chronic amineptin poisoning: Apropos of 6 cases”. Annales de Dermatologie et de Venereologie. 115 (11): 1180—2. PMID 2977081.
^ Teillac D, Weber MJ, Lowenstein W, de Prost Y: [Acne caused by Survector] Ann Dermatol Venereol. 1988;Teillac, D.; Weber, M. J.; Lowenstein, W.; De Prost, Y. (1988). „Acne caused by Survector”. Annales de Dermatologie et de Venereologie. 115 (11): 1183—4. PMID 2977082.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Amineptine

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Vaugeois JM, Corera AT, Deslandes A, Costentin J: Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor. Pharmacol Biochem Behav. Vaugeois, J. M.; Corera, A. T.; Deslandes, A.; Costentin, J. (јун 1999). „Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor”. Pharmacology, Biochemistry, and Behavior. 63 (2): 285—90. PMID 10371658. doi:10.1016/s0091-3057(98)00242-1.

[2] Grupper C: [New iatrogenic acne: acne caused by amineptin (Survector)] Ann Dermatol Venereol. 1988;Grupper, C. (1988). „New iatrogenic acne: Acne caused by amineptin (Survector)”. Annales de Dermatologie et de Venereologie. 115 (11): 1174—6. PMID 2977079.

[3] Thioly-Bensoussan D, Charpentier A, Triller R, Thioly F, Blanchet P, Tricoire N, Noury JY, Grupper C: [Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases] Ann Dermatol Venereol. 1988;Thioly-Bensoussan, D.; Charpentier, A.; Triller, R.; Thioly, F.; Blanchet, P.; Tricoire, N.; Noury, J. Y.; Grupper, C. (1988). „Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases”. Annales de Dermatologie et de Venereologie. 115 (11): 1177—80. PMID 2977080.

[4] Vexiau P, Gourmel B, Husson C, Castot A, Rybojad M, Julien R, Fiet J, Puissant A, Cathelineau G: [Severe lesions of acne type induced by chronic amineptin poisoning: apropos of 6 cases] Ann Dermatol Venereol. 1988;Vexiau, P.; Gourmel, B.; Husson, C.; Castot, A.; Rybojad, M.; Julien, R.; Fiet, J.; Puissant, A.; Cathelineau, G. (1988). „Severe lesions of acne type induced by chronic amineptin poisoning: Apropos of 6 cases”. Annales de Dermatologie et de Venereologie. 115 (11): 1180—2. PMID 2977081.

[5] Teillac D, Weber MJ, Lowenstein W, de Prost Y: [Acne caused by Survector] Ann Dermatol Venereol. 1988;Teillac, D.; Weber, M. J.; Lowenstein, W.; De Prost, Y. (1988). „Acne caused by Survector”. Annales de Dermatologie et de Venereologie. 115 (11): 1183—4. PMID 2977082.

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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