Dekstroamfetamin

Dekstroamfetamin
Nazivi
	Drugi nazivi Amsustain, Dephadren, Dexacaps, Dexadrine
Identifikacija
CAS broj	51-64-9 ;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:4469 ;
ChemSpider	5621 ;
DrugBank	DB01576;
ECHA InfoCard	100.000.103
KEGG	C07884 ;
PubChem C ID	5826;
	SMILES C[C@H](N)CC1=CC=CC=C1; ; ; ; ; ;
Svojstva
Hemijska formula	C9H13N
Molarna masa	135,206
Tačka topljenja	<
Tačka ključanja	203
Farmakologija
Načini upotrebe	Oralno
	Farmakokinetika:
Poluvreme eliminacije	10-28 h
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Dekstroamfetamin je organsko jedinjenje, koje sadrži 9 atoma ugljenika i ima molekulsku masu od 135,206 Da.^[4]^[5]^[6]^[7]^[8]^[9]^[10]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	1
Broj donora vodonika	1
Broj rotacionih veza	2
Particioni koeficijent^[11] (ALogP)	1,6
Rastvorljivost^[12] (logS, log(mol/L))	-2,3
Polarna površina^[13] (PSA, Å²)	26,0

Reference

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Yamada, H.; Baba, T.; Hirata, Y.; Oguri, K.; Yoshimura, H. (новембар 1984). „Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: The role of flavin-containing mono-oxygenase and cytochrome P-450 systems”. Xenobiotica. 14 (11): 861—6. PMID 6506758. doi:10.3109/00498258409151484.
^ Warneke, L. (1990). „Psychostimulants in psychiatry”. Can J Psychiatry. 35 (1): 3—10. PMID 2180548. doi:10.1177/070674379003500102.
^ Wagner, G. J.; Rabkin, R. (2000). „Effects of dextroamphetamine on depression and fatigue in men with HIV: A double-blind, placebo-controlled trial”. J Clin Psychiatry. 61 (6): 436—40. PMID 10901342. doi:10.4088/jcp.v61n0608.
^ Martinsson, L.; Yang, X.; Beck, O.; Wahlgren, N. G.; Eksborg, S. (Sep-Oct). „Pharmacokinetics of dexamphetamine in acute stroke”. Clin Neuropharmacol. 26 (5): 270—6. PMID 14520168. doi:10.1097/00002826-200309000-00012. Непознати параметар |DUPLICATE_date= игнорисан (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Bütefisch, C. M.; Davis, B. C.; Sawaki, L.; Waldvogel, D.; Classen, J.; Kopylev, L.; Cohen, L. G. (јануар 2002). „Modulation of use-dependent plasticity by d-amphetamine”. Ann Neurol. 51 (1): 59—68. PMID 11782985. doi:10.1002/ana.10056.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (I изд.). Oxford University Press. ISBN 978-0-19-850346-0.
Smith, Michael B.; March, Jerry (2007). Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th изд.). New York: Wiley-Interscience. ISBN 0-471-72091-7.
Katritzky A.R.; Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry (Second изд.). Academic Press. ISBN 0080429882.

Spoljašnje veze

Dextroamphetamine

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Yamada, H.; Baba, T.; Hirata, Y.; Oguri, K.; Yoshimura, H. (новембар 1984). „Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: The role of flavin-containing mono-oxygenase and cytochrome P-450 systems”. Xenobiotica. 14 (11): 861—6. PMID 6506758. doi:10.3109/00498258409151484.

[5] Warneke, L. (1990). „Psychostimulants in psychiatry”. Can J Psychiatry. 35 (1): 3—10. PMID 2180548. doi:10.1177/070674379003500102.

[6] Wagner, G. J.; Rabkin, R. (2000). „Effects of dextroamphetamine on depression and fatigue in men with HIV: A double-blind, placebo-controlled trial”. J Clin Psychiatry. 61 (6): 436—40. PMID 10901342. doi:10.4088/jcp.v61n0608.

[7] Martinsson, L.; Yang, X.; Beck, O.; Wahlgren, N. G.; Eksborg, S. (Sep-Oct). „Pharmacokinetics of dexamphetamine in acute stroke”. Clin Neuropharmacol. 26 (5): 270—6. PMID 14520168. doi:10.1097/00002826-200309000-00012. Непознати параметар |DUPLICATE_date= игнорисан (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[8] Bütefisch, C. M.; Davis, B. C.; Sawaki, L.; Waldvogel, D.; Classen, J.; Kopylev, L.; Cohen, L. G. (јануар 2002). „Modulation of use-dependent plasticity by d-amphetamine”. Ann Neurol. 51 (1): 59—68. PMID 11782985. doi:10.1002/ana.10056.

[9] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[10] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[11] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[12] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[13] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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