Ekso-(1-4)-α-D-glukanska lijaza

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Ekso-(1-4)-α-D-glukanska lijaza
Identifikatori
EC broj 4.2.2.13
CAS broj 148710-18-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Ekso-(1-4)-α-D-glukanska lijaza (EC 4.2.2.13, alfa-(1->4)-glukan 1,5-anhidro-D-fruktozna eliminaza, alfa-1,4-glukan ekso-lijaza, alfa-1,4-glukan lijaza, Glaza) je enzim sa sistematskim imenom (1->4)-alfa-D-glukan ekso-4-lijaza (formira 1,5-anhidro-D-fruktoza).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

linearni alfa-glukan \rightleftharpoons (N-1) 1,5-anhidro-D-fruktoza + D-glukoza

Ovaj enzim katalizuje sekvencinu degradaciju (1->4)-alfa-D-glukana sa neredukujućeg kraja.

Reference[уреди]

  1. Yu, S., Kenne, L., Pedersén, M. (1993). „α-1,4-Glucan lyase, a new class of starch/glycogen degrading enzyme. I. Efficient purification and characterization from red seaweeds“. Biochim. Biophys. Acta 1156: 313-320. PMID 8461323. 
  2. Yu, S., Pedersén, M. (1993). „α-1,4-Glucan lyase, a new class of starch/glycogen degrading enzyme. II. Subcellular localization and partial amino-acid sequence“. Planta 191: 137-142. PMID 7763826. 
  3. Yu, S., Ahmad, T., Kenne, L. and Pedersén, M. (1995). „α-1,4-Glucan lyase, a new class of starch/glycogen degrading enzyme. III. Substrate specificity, mode of action, and cleavage mechanism“. Biochim. Biophys. Acta 1244: 1-9. PMID 7766642. 
  4. Yu, S., Christensen, T.M., Kragh, K.M., Bojsen, K. and Marcussen, J. (1997). „Efficient purification, characterization and partial amino acid sequencing of two α-1,4-glucan lyases from fungi“. Biochim. Biophys. Acta 1339: 311-320. PMID 9187252. 
  5. Yu, S., Bojsen, K., Svensson, B. and Marcussen, J. (1999). „α-1,4-glucan lyases producing 1,5-anhydro-D-fructose from starch and glycogen have sequence similarity to α-glucosidases“. Biochim. Biophys. Acta 1433: 1-15. PMID 10446355. 
  6. Lee, S.S., Yu, S. and Withers, S.G. (2002). „α-1,4-Glucan lyase performs a trans-elimination via a nucleophilic displacement followed by a syn-elimination“. J. Am. Chem. Soc. 124: 4948-4949. PMID 11982345. 
  7. Lee, S.S., Yu, S. and Withers, S.G. (2003). „Detailed dissection of a new mechanism for glycoside cleavage: α-1,4-glucan lyase“. Biochemistry 42: 13081-13090. PMID 14596624. 

Literatura[уреди]

Spoljašnje vezе[уреди]