Glutation amid reduktaza
| Glutation amid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.1.16 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glutation amid reduktaza (EC 1.8.1.16, GAR) je enzim sa sistematskim imenom glutation amid:NAD+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 glutation amid + NAD+ glutation amid disulfid + NADH + H+
Ovaj enzim je dimerni flavoprotein (FAD). On obnavlja glutation amid disulfid, koji se formira tokom redukcije peroksida enzimom EC 1.11.1.17 (glutation amid-zavisnom peroksidazom), nazad u glutationski amid (on katalizuje reakciju reverznom smeru od prikazanog).
Reference[уреди | уреди извор]
- ^ Vergauwen, B., Pauwels, F., Jacquemotte, F., Meyer, T.E., Cusanovich, M.A., Bartsch, R.G. and Van Beeumen, J.J. (2001). „Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling”. J. Biol. Chem. 276: 20890—20897. PMID 11399772.
- ^ Vergauwen, B., Van Petegem, F., Remaut, H., Pauwels, F. and Van Beeumen, J.J. (2002). „Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile”. Acta Crystallogr. D Biol. Crystallogr. 58: 339—340. PMID 11807270.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Glutathione+amide+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
