Hidromorfon

Hidromorfon
Klinički podaci
Prodajno ime	Dilaudid, Dilaudid Oros, Dilaudid-hp, DiMo
Drugs.com	Monografija
Način primene	Oralno, intramaskularno, intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	2,6 h
Izlučivanje	Renalno
Identifikatori
CAS broj	466-99-9
ATC kod	N02AA03 (WHO)
PubChem	CID 5284570
DrugBank	DB00327
ChemSpider	4447624
KEGG	C07042
ChEBI	CHEBI:5790
ChEMBL	CHEMBL398707
Hemijski podaci
Formula	C17H19NO3
Molarna masa	285,338
	SMILES [H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])CCC2=O; ;
	InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1 ; Key:WVLOADHCBXTIJK-YNHQPCIGSA-N ;
Fizički podaci
Tačka topljenja	2.665 °C (4.829 °F)

Hidromorfon je organsko jedinjenje, koje sadrži 17 atoma ugljenika i ima molekulsku masu od 285,338 Da.^[1]^[2]^[3]^[4]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	4
Broj donora vodonika	1
Broj rotacionih veza	0
Particioni koeficijent^[5] (ALogP)	1,7
Rastvorljivost^[6] (logS, log(mol/L))	-2,0
Polarna površina^[7] (PSA, Å²)	49,8

Reference

^ Coda, B. A.; Rudy AC; Archer SM; Wermeling DP (јул 2003). „Pharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers”. Anesth Analg. 97 (1): 117—23. , table of contents. PMID 12818953
^ Vallner, J. J.; Stewart JT; Kotzan JA; Kirsten EB; Honigberg IL (април 1981). „Pharmacokinetics and bioavailability of hydromorphone following intravenous and oral administration to human subjects”. J Clin Pharmacol. 21 (4): 152—6. PMID 6165742.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Hydromorphone

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Coda, B. A.; Rudy AC; Archer SM; Wermeling DP (јул 2003). „Pharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers”. Anesth Analg. 97 (1): 117—23. , table of contents. PMID 12818953

[2] Vallner, J. J.; Stewart JT; Kotzan JA; Kirsten EB; Honigberg IL (април 1981). „Pharmacokinetics and bioavailability of hydromorphone following intravenous and oral administration to human subjects”. J Clin Pharmacol. 21 (4): 152—6. PMID 6165742.

[3] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[4] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[5] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[6] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[7] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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