Makrofagna elastaza
| Makrofagna elastaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.65 | ||||||||
| CAS broj | 2594837 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Makrofagna elastaza (EC 3.4.24.65, metaloelastaza, ljudska makrofagna metaloelastaza (HME)) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza rastvornog i nerastvornog elastina. Do specifičnog razlaganja takođe dolazi u Ala14-Leu- i -Tyr16-Leu- u B lancu insulina
Ovaj enzim se formira iz proenzima sa masom od 53 kDa.
Reference
[уреди | уреди извор]- ^ Banda, M.J. & Werb, Z. (1981). „Mouse macrophage elastase. Purification and characterization as a metalloproteinase”. Biochem. J. 193: 589—605. PMID 7030312.
- ^ Kettner, C., Shaw, E., White, R. and Janoff, A. (1981). „The specificity of macrophage elastase on the insulin B-chain”. Biochem. J. 195: 369—372. PMID 7032505.
- ^ Shapiro, S.D., Griffin, G.L., Gilbert, D.J., Jenkins, N.A., Copeland, N.G., Welgus, H.G., Senior, R.M. and Ley, T.J. (1992). „Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase”. J. Biol. Chem. 267: 4664—4671. PMID 1537850.
- ^ Shapiro, S.D., Kobayashi, D.K. and Ley, T.J. (1993). „Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages”. J. Biol. Chem. 268: 23824—23829. PMID 8226919.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Macrophage+elastase на US National Library of Medicine Medical Subject Headings (MeSH)
