Nikotin dehidrogenaza
| Nikotin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.99.4 | ||||||||
| CAS broj | 37256-31-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Nikotin dehidrogenaza (EC 1.5.99.4, nikotinska oksidaza, D-nikotinska oksidaza, nikotin:(akceptor) 6-oksidoreduktaza (hidroksilacija), L-nikotinska oksidaza) je enzim sa sistematskim imenom nikotin:akceptor 6-oksidoreduktaza (hidroksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (S)-nikotin + akceptor + H2O (S)-6-hidroksinikotin + redukovani akceptor
Ovaj enzim je metaloprotein (FMN). On može da deljuje na prirodni (S)-enantiomer i na sintetički (R)-enantiomer nikotina.
Reference[уреди | уреди извор]
- ^ Behrman, E.J. & Stanier, R.Y. (1957). „The bacterial oxidation of nicotinic acid”. J. Biol. Chem. 228: 923—945. PMID 13475371.
- ^ Decker, K. & Bleeg, H. (1965). „Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans”. Biochim. Biophys. Acta. 105: 313—324. PMID 5849820.
- ^ Hochstein, L.I. & Dalton, B.P. (1967). „The purification and properties of nicotine oxidase”. Biochim. Biophys. Acta. 139: 56—68. PMID 4962139.
- ^ Hochstein, L.I. & Rittenberg, S.C. (1959). „The bacterial oxidation of nicotine. II. The isolation of the first oxidative product and its identification as (1)-6-hydroxynicotine”. J. Biol. Chem. 234: 156—160. PMID 13610912.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Nicotine+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
