Peginesatid

Peginesatid
Klinički podaci
Drugs.com	Monografija
Način primene	Intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	25 h
Identifikatori
CAS broj	913976-27-9
ATC kod	B03XA04 (WHO)
DrugBank	DB08894
ChEBI	CHEBI:66895
Hemijski podaci
Formula	C233H352N62O60S6
Molarna masa	0,000

Peginesatid je organsko jedinjenje, koje sadrži 233 atoma ugljenika i ima molekulsku masu od 0,000 Da.^[1]^[2]^[3]^[4]^[5]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	70
Broj donora vodonika	57
Broj rotacionih veza	128
Particioni koeficijent^[6] (ALogP)	-11,2
Rastvorljivost^[7] (logS, log(mol/L))	-35,7
Polarna površina^[8] (PSA, Å²)	1958,4

Reference

^ Schmid H: Peginesatide for the treatment of renal disease-induced anemia. Expert Opin Pharmacother. Schmid, Holger (2013 May). „Peginesatide for the treatment of renal disease-induced anemia”. Expert Opinion on Pharmacotherapy. 14 (7): 937—948. PMID 23506424. doi:10.1517/14656566.2013.780695. Проверите вредност парамет(а)ра за датум: |date= (помоћ).. Epub 2013 Mar 18.
^ Woodburn KW, Holmes CP, Wilson SD, Fong KL, Press RJ, Moriya Y, Tagawa Y: Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats. Xenobiotica. Woodburn, Kathryn W.; Holmes, Christopher P.; Wilson, Susan D.; Fong, Kei-Lai; Press, Randall J.; Moriya, Yuu; Tagawa, Yoshihiko (2012 Jul). „Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats”. Xenobiotica. 42 (7): 660—670. PMC 3409459 . PMID 22188389. doi:10.3109/00498254.2011.649310. Проверите вредност парамет(а)ра за датум: |date= (помоћ).. Epub 2011 Dec 22.
^ Woodburn KW, Fong KL, Wilson SD, Sloneker S, Strzemienski P, Solon E, Moriya Y, Tagawa Y: Peginesatide clearance, distribution, metabolism, and excretion in monkeys following intravenous administration. Drug Metab Dispos. Woodburn, Kathryn W.; Fong, Kei-Lai; Wilson, Susan D.; Sloneker, Steven; Strzemienski, Paul; Solon, Eric; Moriya, Yuu; Tagawa, Yoshihiko (2013 Apr). „Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration”. Drug Metabolism and Disposition. 41 (4): 774—784. PMID 23318685. doi:10.1124/dmd.112.048033. Проверите вредност парамет(а)ра за датум: |date= (помоћ).. Epub 2013 Jan 14.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Peginesatide

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[1] Schmid H: Peginesatide for the treatment of renal disease-induced anemia. Expert Opin Pharmacother. Schmid, Holger (2013 May). „Peginesatide for the treatment of renal disease-induced anemia”. Expert Opinion on Pharmacotherapy. 14 (7): 937—948. PMID 23506424. doi:10.1517/14656566.2013.780695. Проверите вредност парамет(а)ра за датум: |date= (помоћ).. Epub 2013 Mar 18.

[2] Woodburn KW, Holmes CP, Wilson SD, Fong KL, Press RJ, Moriya Y, Tagawa Y: Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats. Xenobiotica. Woodburn, Kathryn W.; Holmes, Christopher P.; Wilson, Susan D.; Fong, Kei-Lai; Press, Randall J.; Moriya, Yuu; Tagawa, Yoshihiko (2012 Jul). „Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats”. Xenobiotica. 42 (7): 660—670. PMC 3409459 . PMID 22188389. doi:10.3109/00498254.2011.649310. Проверите вредност парамет(а)ра за датум: |date= (помоћ).. Epub 2011 Dec 22.

[3] Woodburn KW, Fong KL, Wilson SD, Sloneker S, Strzemienski P, Solon E, Moriya Y, Tagawa Y: Peginesatide clearance, distribution, metabolism, and excretion in monkeys following intravenous administration. Drug Metab Dispos. Woodburn, Kathryn W.; Fong, Kei-Lai; Wilson, Susan D.; Sloneker, Steven; Strzemienski, Paul; Solon, Eric; Moriya, Yuu; Tagawa, Yoshihiko (2013 Apr). „Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration”. Drug Metabolism and Disposition. 41 (4): 774—784. PMID 23318685. doi:10.1124/dmd.112.048033. Проверите вредност парамет(а)ра за датум: |date= (помоћ).. Epub 2013 Jan 14.

[4] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[6] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[7] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[8] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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