Peptid-metionin (R)-S-oksid reduktaza

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Peptid-metionin (R)-S-oksid reduktaza
EC broj
Baze podataka
IntEnz IntEnz pregled
ExPASy NiceZyme pregled
KEGG KEGG pristup
MetaCyc metabolički put
PRIAM profil
Strukture PBP RCSB PDB PDBe PDBsum

Peptid-metionin (R)-S-oksid reduktaza (EC, MsrB, metionin sulfoksidna reduktaza (nespecifična), pMSR, metionin S-oksidna reduktaza (nespecifična), selenoprotein R, metionin S-oksidna reduktaza (oksiduje R-formu), metionin sulfoksid reduktaza B, SelR, SelX, PilB, pRMsr) je enzim sa sistematskim imenom peptid-metionin:tioredoksin-disulfid S-oksidoreduktaza (formira metionin (R)-S-oksid).[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

peptid-L-metionin + tioredoksin disulfid +H2O peptid-L-metionin (R)-S-oksid + tioredoksin

Ova reakcija teče u reverznom smeru. Enzim manifestuje visoku specifičnost za redukciju R-forme L-metionin S-oksida. On brže deluje na L-metionin S-oksid nego na D-metionin S-oksid. Aktivnost je veća na ostataku peptida nego na slobodnoj aminokiselini.


  1. Moskovitz, J., Singh, V.K., Requena, J., Wilkinson, B.J., Jayaswal, R.K. and Stadtman, E.R. (2002). „Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity”. Biochem. Biophys. Res. Commun. 290: 62—65. PMID 11779133. 
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  7. Kauffmann, B., Aubry, A. and Favier, F. (2005). „The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions”. Biochim. Biophys. Acta. 1703: 249—260. PMID 15680233. 
  8. Vougier, S., Mary, J. and Friguet, B. (2003). „Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells”. Biochem. J. 373: 531—537. PMID 12693988. 
  9. Olry, A., Boschi-Muller, S., Marraud, M., Sanglier-Cianferani, S., Van Dorsselear, A. and Branlant, G. (2002). „Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis”. J. Biol. Chem. 277: 12016—12022. PMID 11812798. 
  10. Sagher, D., Brunell, D., Hejtmancik, J.F., Kantorow, M., Brot, N. and Weissbach, H. (2006). „Thionein can serve as a reducing agent for the methionine sulfoxide reductases”. Proc. Natl. Acad. Sci. USA. 103: 8656—8661. PMID 16735467. 


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