Peptid-metionin (R)-S-oksid reduktaza

Из Википедије, слободне енциклопедије
Peptid-metionin (R)-S-oksid reduktaza
EC broj
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Peptid-metionin (R)-S-oksid reduktaza (EC, MsrB, metionin sulfoksidna reduktaza (nespecifična), pMSR, metionin S-oksidna reduktaza (nespecifična), selenoprotein R, metionin S-oksidna reduktaza (oksiduje R-formu), metionin sulfoksid reduktaza B, SelR, SelX, PilB, pRMsr) je enzim sa sistematskim imenom peptid-metionin:tioredoksin-disulfid S-oksidoreduktaza (formira metionin (R)-S-oksid).[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

peptid-L-metionin + tioredoksin disulfid +H2O \rightleftharpoons peptid-L-metionin (R)-S-oksid + tioredoksin

Ova reakcija teče u reverznom smeru. Enzim manifestuje visoku specifičnost za redukciju R-forme L-metionin S-oksida. On brže deluje na L-metionin S-oksid nego na D-metionin S-oksid. Aktivnost je veća na ostataku peptida nego na slobodnoj aminokiselini.


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  10. Sagher, D., Brunell, D., Hejtmancik, J.F., Kantorow, M., Brot, N. and Weissbach, H. (2006). „Thionein can serve as a reducing agent for the methionine sulfoxide reductases”. Proc. Natl. Acad. Sci. USA 103: 8656-8661. PMID 16735467. 


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