Peptid-metionin (S)-S-oksid reduktaza
| Peptid-metionin (S)-S-oksid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.4.11 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Peptid-metionin (S)-S-oksid reduktaza (EC 1.8.4.11, MsrA, metionin sulfoksidna reduktaza (nespecifična), metionin sulphoksidna reduktaza A, metionin S-oksidna reduktaza (nespecifična), metionin S-oksidna reduktaza, metionin sulfoksidna reduktaza A, peptid metionin sulfoksidna reduktaza) je enzim sa sistematskim imenom peptid-L-metionin:tioredoksin-disulfid S-oksidoreduktaza (formira L-metionin (S)-S-oksid).[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) peptid-L-metionin + tioredoksin disulfid + H2O peptid-L-metionin (S)-S-oksid + tioredoksin
- (2) L-metionin + tioredoksin disulfid + H2O L-metionin (S)-S-oksid + tioredoksin
Ova reakcija teče u reverznom smeru. Enzim manifestuje visoku specifičnost za redukciju S-forms L-metionin S-oksid. On deluje brže na ostatak u peptidu, nego na slobodnu aminokiselinu.
Reference[уреди | уреди извор]
- ^ Moskovitz, J., Singh, V.K., Requena, J., Wilkinson, B.J., Jayaswal, R.K. and Stadtman, E.R. (2002). „Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity”. Biochem. Biophys. Res. Commun. 290: 62—65. PMID 11779133.
- ^ Taylor, A.B., Benglis, D.M., Jr., Dhandayuthapani, S. and Hart, P.J. (2003). „Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine”. J. Bacteriol. 185: 4119—4126. PMID 12837786.
- ^ Singh, V.K. & Moskovitz, J. (2003). „Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress”. Microbiology. 149: 2739—2747. PMID 14523107.
- ^ Boschi-Muller, S., Olry, A., Antoine, M. and Branlant, G. (2005). „The enzymology and biochemistry of methionine sulfoxide reductases”. Biochim. Biophys. Acta. 1703: 231—238. PMID 15680231.
- ^ Ezraty, B., Aussel, L. and Barras, F. (2005). „Methionine sulfoxide reductases in prokaryotes”. Biochim. Biophys. Acta. 1703: 221—229. PMID 15680230.
- ^ Weissbach, H., Resnick, L. and Brot, N. (2005). „Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage”. Biochim. Biophys. Acta. 1703: 203—212. PMID 15680228.
- ^ Kauffmann, B., Aubry, A. and Favier, F. (2005). „The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions”. Biochim. Biophys. Acta. 1703: 249—260. PMID 15680233.
- ^ Vougier, S., Mary, J. and Friguet, B. (2003). „Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells”. Biochem. J. 373: 531—537. PMID 12693988.
- ^ Olry, A., Boschi-Muller, S., Marraud, M., Sanglier-Cianferani, S., Van Dorsselear, A. and Branlant, G. (2002). „Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis”. J. Biol. Chem. 277: 12016—12022. PMID 11812798.
- ^ Brot, N., Weissbach, L., Werth, J. and Weissbach, H. (1981). „Enzymatic reduction of protein-bound methionine sulfoxide”. Proc. Natl. Acad. Sci. USA. 78: 2155—2158. PMID 7017726.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Peptide-methionine+(S)-S-oxide+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
