Sibutramin

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Sibutramin
Sibutramine2DACS.svg
Sibutramine3Dan.gif
Klinički podaci
Prodajno ime Butramin, Medaria, Meridia, Reductil
Drugs.com Monografija
Način primene Oralno
Farmakokinetički podaci
Poluvreme eliminacije 1,1 h
Identifikatori
CAS broj 106650-56-0 ДаY
ATC kod A08AA10 (WHO)
PubChem CID 5210
IUPHAR/BPS 2586
DrugBank DB01105 ДаY
ChemSpider 5021 ДаY
KEGG C07247 ДаY
ChEMBL CHEMBL1419 ДаY
Hemijski podaci
Formula C17H26ClN
Molarna masa 279,848
Fizički podaci
Tačka topljenja 191—192 °C (376—378 °F)

Sibutramin je organsko jedinjenje, koje sadrži 17 atoma ugljenika i ima molekulsku masu od 279,848 Da.[1][2][3][4][5][6]

Osobine[уреди]

Osobina Vrednost
Broj akceptora vodonika 1
Broj donora vodonika 0
Broj rotacionih veza 5
Particioni koeficijent[7] (ALogP) 5,2
Rastvorljivost[8] (logS, log(mol/L)) -5,6
Polarna površina[9] (PSA, Å2) 3,2

Reference[уреди]

  1. ^ Sharma B, Henderson DC: Sibutramine: current status as an anti-obesity drug and its future perspectives. Expert Opin Pharmacother. 2008 Aug;9(12):2161-73. PMID 18671470
  2. ^ Tziomalos K, Krassas GE, Tzotzas T: The use of sibutramine in the management of obesity and related disorders: an update. Vasc Health Risk Manag. 2009;5(1):441-52. PMID 19475780
  3. ^ Heal DJ, Aspley S, Prow MR, Jackson HC, Martin KF, Cheetham SC: Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine. Int J Obes Relat Metab Disord. 1998 Aug;22 Suppl 1:S18-28; discussion S29. PMID 9758240
  4. ^ Stock MJ: Sibutramine: a review of the pharmacology of a novel anti-obesity agent. Int J Obes Relat Metab Disord. 1997 Mar;21 Suppl 1:S25-9. PMID 9130038
  5. ^ Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil). уреди
  6. ^ Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil). уреди
  7. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  8. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. doi:10.1021/ci000392t. PMID 11749573.  уреди
  9. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. doi:10.1021/jm000942e. PMID 11020286.  уреди

Literatura[уреди]

Spoljašnje veze[уреди]

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