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Tiol oksidaza

С Википедије, слободне енциклопедије
Tiol oksidaza
Identifikatori
EC broj1.8.3.2
CAS broj9029-39-4
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Tiol oksidaza (EC 1.8.3.2, sulfhidrilna oksidaza) je enzim sa sistematskim imenom tiol:kiseonik oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10][11] Ovaj enzim katalizuje sledeću hemijsku reakciju:

2 R'C(R)SH + O2 R'C(R)S-S(R)CR' +H2O2

R može da bude =S ili =O, kao i niz drugih grupa. Enzim nije specifičan za R'.

  1. ^ Aurbach, G.D. & Jakoby, W.B. (1962). „The multiple functions of thiooxidase”. J. Biol. Chem. 237: 565—568. PMID 13863296. 
  2. ^ Neufeld, H.A., Green, L.F., Latterell, F.M. and Weintraub, R.L. (1958). „Thiooxidase, a new sulfhydryl-oxidizing enzyme from Piricularia oryzae and Polyporus vesicolor. J. Biol. Chem. 232: 1093—1099. PMID 13549489. 
  3. ^ Ostrowski, M.C. & Kistler, W.S. (1980). „Properties of a flavoprotein sulfhydryl oxidase from rat seminal vesicle secretion”. Biochemistry. 19: 2639—2645. PMID 7397095. 
  4. ^ Hoober, K.L., Joneja, B., White, H.B., 3rd and Thorpe, C. (1996). „A sulfhydryl oxidase from chicken egg white”. J. Biol. Chem. 271: 30510—30516. PMID 8940019. 
  5. ^ Jaje, J., Wolcott, H.N., Fadugba, O., Cripps, D., Yang, A.J., Mather, I.H. and Thorpe, C. (2007). „A flavin-dependent sulfhydryl oxidase in bovine milk”. Biochemistry. 46: 13031—13040. PMID 17944490. 
  6. ^ Sevier, C.S., Cuozzo, J.W., Vala, A., Aslund, F. and Kaiser, C.A. (2001). „A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation”. Nat. Cell Biol. 3: 874—882. PMID 11584268. 
  7. ^ Dabir, D.V., Leverich, E.P., Kim, S.K., Tsai, F.D., Hirasawa, M., Knaff, D.B. and Koehler, C.M. (2007). „A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1”. EMBO J. 26: 4801—4811. PMID 17972915. 
  8. ^ Farrell, S.R. & Thorpe, C. (2005). „Augmenter of liver regeneration: a flavin-dependent sulfhydryl oxidase with cytochrome c reductase activity”. Biochemistry. 44: 1532—1541. PMID 15683237. 
  9. ^ Gross, E., Sevier, C.S., Heldman, N., Vitu, E., Bentzur, M., Kaiser, C.A., Thorpe, C. and Fass, D. (2006). „Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p”. Proc. Natl. Acad. Sci. USA. 103: 299—304. PMID 16407158. 
  10. ^ de la Motte, R.S. & Wagner, F.W. (1987). „Aspergillus niger sulfhydryl oxidase”. Biochemistry. 26: 7363—7371. PMID 3427078. 
  11. ^ Riemer, J., Bulleid, N. and Herrmann, J.M. (2009). „Disulfide formation in the ER and mitochondria: two solutions to a common process”. Science. 324: 1284—1287. PMID 19498160. 

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