U46619

Из Википедије, слободне енциклопедије
U46619
IUPAC ime
Identifikacija
CAS registarski broj 56985-40-1
PubChem[1][2] 5311493
ChEMBL[3] CHEMBL357834
IUPHAR ligand 1888
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C21H34O4
Molarna masa 350,49 g/mol

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

U46619 je stabilni sintetički analog prostaglandina PGH2 koji je prvi put pripremnljen 1975.[4] U46619 je vazokonstriktor koji oponaša hidroosmotičko dejstvo vazopresina.[5] On takođe oponaša dejstvo tromboksana putem aktivacije fosfolipaze C.[6][7]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  4. ^ Bundy, G. L. (1975). „Synthesis of prostaglandin endoperoxide analogs“. Tetrahedron Letters 24 (24): 1957–1960. DOI:10.1016/S0040-4039(00)72333-1. 
  5. ^ Burch, Ronald M.; Halushka, Perry V. (1983). „Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport“. Journal of Pharmacology and Experimental Therapeutics 224 (1): 108–17. PMID 6294273. 
  6. ^ Rittenhouse, Susan E. (1984). „Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP“. Biochemical Journal 222 (1): 103–110. PMC 1144149. PMID 6433894. 
  7. ^ Michael P. Walsh, et all (August 2005). „Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697“. Biochem. J. 389 (Pt 3): 763–74. DOI:10.1042/BJ20050237. PMC 1180727. PMID 15823093. 

Spoljašnje veze[уреди]