UGT1A10

UGT1A10
Identifikatori
Alijasi	UGT1A10
Spoljašnji ID	OMIM: 606435 MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A10
Genska lokacija (miš)
Hr.	Chromosome 1 (mouse)
Kraj	88,146,719 bp
Genska ontologija
Molecular function	• transferase activity; • retinoic acid binding; • hexosyltransferase activity; • protein homodimerization activity; • glycosyltransferase activity; • protein heterodimerization activity; • enzyme binding; • protein kinase C binding; • glucuronosyltransferase activity; • UDP-glycosyltransferase activity;
Cellular component	• саставни део мембране; • мембрана; • intracellular membrane-bounded organelle; • ендоплазматични ретикулум; • endoplasmic reticulum membrane;
Biological process	• negative regulation of cellular glucuronidation; • xenobiotic glucuronidation; • flavone metabolic process; • метаболизам; • negative regulation of glucuronosyltransferase activity; • negative regulation of fatty acid metabolic process; • Glukuronidacija; • flavonoid glucuronidation;
	Sources:Amigo / QuickGO
Ortolozi
	54575
	394434
	ENSG00000242515
	ENSMUSG00000090175
	Q9HAW8
	Q62452
	NM_019075
	NM_201644
	NP_061948
	NP_964006
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glukuronoziltransferaza 1-10 je enzim koji je kod ljudi kodiran genom UGT1A10.^[4]^[5]^[6]

Interaktivna mapa putanja[уреди | уреди извор]

Kliknite na gene, proteine i metabolite u nastavku za veze s odgovarajućim člancima. ^{[§ 1]}

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|{{{bSize}}}px|alt=Irinotekanski put edit]]

Irinotekanski put edit

^ The interactive pathway map can be edited at WikiPathways: „IrinotecanPathway_WP46359”.

Reference[уреди | уреди извор]

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (октобар 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001.
^ Mojarrabi B, Mackenzie PI (октобар 1997). „The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid”. Biochem Biophys Res Commun. 238 (3): 775—8. PMID 9325166. doi:10.1006/bbrc.1997.7388.
^ „Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10”.

Literatura[уреди | уреди извор]

Tukey RH, Strassburg CP (2000). „Human UDP-glucuronosyltransferases: metabolism, expression, and disease”. Annu. Rev. Pharmacol. Toxicol. 40: 581—616. PMID 10836148. doi:10.1146/annurev.pharmtox.40.1.581.
Tukey RH, Strassburg CP (2001). „Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract”. Mol. Pharmacol. 59 (3): 405—14. PMID 11179432. S2CID 21500183. doi:10.1124/mol.59.3.405.
King CD, Rios GR, Green MD, Tephly TR (2001). „UDP-glucuronosyltransferases”. Curr. Drug Metab. 1 (2): 143—61. PMID 11465080. doi:10.2174/1389200003339171.
Harding D, Jeremiah SJ, Povey S, Burchell B (1990). „Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1”. Ann. Hum. Genet. 54 (Pt 1): 17—21. PMID 2108603. S2CID 35661967. doi:10.1111/j.1469-1809.1990.tb00356.x.
van Es HH; Bout A; Liu J; et al. (1993). „Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37”. Cytogenet. Cell Genet. 63 (2): 114—6. PMID 8467709. doi:10.1159/000133513.
Strassburg CP, Oldhafer K, Manns MP, Tukey RH (1997). „Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue”. Mol. Pharmacol. 52 (2): 212—20. PMID 9271343. S2CID 37098463. doi:10.1124/mol.52.2.212.
Mojarrabi B, Mackenzie PI (1998). „Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon”. Biochem. Biophys. Res. Commun. 247 (3): 704—9. PMID 9647757. doi:10.1006/bbrc.1998.8843.
Strassburg CP; Strassburg A; Nguyen N; et al. (1999). „Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus”. Biochem. J. 338 (2): 489—98. PMC 1220077 . PMID 10024527. doi:10.1042/0264-6021:3380489.
Cheng Z, Radominska-Pandya A, Tephly TR (1999). „Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10”. Drug Metab. Dispos. 27 (10): 1165—70. PMID 10497143.
Strassburg CP; Kneip S; Topp J; et al. (2000). „Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine”. J. Biol. Chem. 275 (46): 36164—71. PMID 10748067. doi:10.1074/jbc.M002180200 .
Gong QH; Cho JW; Huang T; et al. (2001). „Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus”. Pharmacogenetics. 11 (4): 357—68. PMID 11434514. doi:10.1097/00008571-200106000-00011.
Zheng Z, Fang JL, Lazarus P (2002). „Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues”. Drug Metab. Dispos. 30 (4): 397—403. PMID 11901093. doi:10.1124/dmd.30.4.397.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Jinno H; Saeki M; Tanaka-Kagawa T; et al. (2003). „Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10”. Drug Metab. Dispos. 31 (5): 528—32. PMID 12695339. doi:10.1124/dmd.31.5.528.

[WikiPathways-7] The interactive pathway map can be edited at WikiPathways: „IrinotecanPathway_WP46359”.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9295054-4] Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (октобар 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001.

[pmid9325166-5] Mojarrabi B, Mackenzie PI (октобар 1997). „The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid”. Biochem Biophys Res Commun. 238 (3): 775—8. PMID 9325166. doi:10.1006/bbrc.1997.7388.

[entrez-6] „Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10”.

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