UGT1A9

UGT1A9
Identifikatori
Alijasi	UGT1A9
Spoljašnji ID	OMIM: 606434 MGI: 3580642 HomoloGene: 133281 GeneCards: UGT1A9
Genska lokacija (miš)
Hr.	Chromosome 1 (mouse)
Kraj	88,146,726 bp
Genska ontologija
Molecular function	• transferase activity; • GO:0048551 enzyme inhibitor activity; • retinoic acid binding; • hexosyltransferase activity; • protein homodimerization activity; • glycosyltransferase activity; • glucuronosyltransferase activity; • protein heterodimerization activity; • enzyme binding; • UDP-glycosyltransferase activity;
Cellular component	• саставни део мембране; • endoplasmic reticulum membrane; • мембрана; • intracellular membrane-bounded organelle; • ендоплазматични ретикулум;
Biological process	• retinoic acid metabolic process; • negative regulation of cellular glucuronidation; • Glukuronidacija; • flavonoid glucuronidation; • xenobiotic glucuronidation; • flavone metabolic process; • xenobiotic metabolic process; • negative regulation of glucuronosyltransferase activity; • negative regulation of fatty acid metabolic process; • regulation of lipid metabolic process; • метаболизам;
	Sources:Amigo / QuickGO
Ortolozi
	54600
	394430
	ENSG00000241119
	ENSMUSG00000090165
	O60656
	n/a
	NM_021027
	NM_201641
	NP_066307
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glukuronoziltransferaza 1-9 je enzim koji je kod ljudi kodiran genom UGT1A9.^[4]^[5]^[6]^[7]

Interaktivna mapa putanja[уреди | уреди извор]

Kliknite na gene, proteine i metabolite u nastavku za veze s odgovarajućim člancima. ^{[§ 1]}

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|{{{bSize}}}px|alt=Irinotekanski put edit]]

Irinotekanski put edit

^ The interactive pathway map can be edited at WikiPathways: „IrinotecanPathway_WP46359”.

Medicinsko hemijski primeri[уреди | уреди извор]

Tokom optimizacije inicijalnih inhibitora HSD17B13 primećena je značajna glukuronidacija fenolnog dela in vitro i in vivo.^[8] UGT fenotipizacija je otkrila da je UGT1A9 glavni doprinosilac glukuronidaciji. Pored toga, sprovedene su studije tkivne raspodele kao i izlučivanja putem žuči.

Reference[уреди | уреди извор]

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000090165 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wooster R, Sutherland L, Ebner T, Clarke D, Da Cruz e Silva O, Burchell B (септембар 1991). „Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family”. Biochem. J. 278 (2): 465—9. PMC 1151367 . PMID 1910331. doi:10.1042/bj2780465.
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (октобар 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001.
^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (март 1992). „A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini”. J Biol Chem. 267 (5): 3257—61. PMID 1339448. doi:10.1016/S0021-9258(19)50724-4 .
^ „Entrez Gene: UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9”.
^ „Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science”. Journal of Medicinal Chemistry.

Literatura[уреди | уреди извор]

Innocenti F, Kroetz DL, Schuetz E, et al. (2009). „Comprehensive Pharmacogenetic Analysis of Irinotecan Neutropenia and Pharmacokinetics”. J. Clin. Oncol. 27 (16): 2604—14. PMC 2690389 . PMID 19349540. doi:10.1200/JCO.2008.20.6300.
Holmes MV, Shah T, Vickery C, et al. (2009). Luo Y, ур. „Fulfilling the Promise of Personalized Medicine? Systematic Review and Field Synopsis of Pharmacogenetic Studies”. PLOS ONE. 4 (12): e7960. Bibcode:2009PLoSO...4.7960H. PMC 2778625 . PMID 19956635. doi:10.1371/journal.pone.0007960 .
Prausa SE, Fukuda T, Maseck D, et al. (2009). „UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients”. Clin. Pharmacol. Ther. 85 (5): 495—500. PMID 19225446. S2CID 33309241. doi:10.1038/clpt.2009.3.
Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). „Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy”. Nat. Genet. 41 (12): 1345—9. PMID 19898482. S2CID 21293339. doi:10.1038/ng.478.
Korprasertthaworn P, Udomuksorn W, Yoovathaworn K (2009). „Three novel single nucleotide polymorphisms of UGT1A9 in a Thai population”. Drug Metab. Pharmacokinet. 24 (5): 482—5. PMID 19881262. doi:10.2133/dmpk.24.482.
Nakajima M, Koga T, Sakai H, et al. (2010). „N-Glycosylation plays a role in protein folding of human UGT1A9”. Biochem. Pharmacol. 79 (8): 1165—72. PMID 19951703. S2CID 11013645. doi:10.1016/j.bcp.2009.11.020. hdl:2297/23493 .
van Schaik RH, van Agteren M, de Fijter JW, et al. (2009). „UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients”. Clin. Pharmacol. Ther. 86 (3): 319—27. PMID 19494809. S2CID 21082902. doi:10.1038/clpt.2009.83.
Sanna S, Busonero F, Maschio A, et al. (2009). „Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia”. Hum. Mol. Genet. 18 (14): 2711—8. PMC 2701337 . PMID 19419973. doi:10.1093/hmg/ddp203.
King CD, Rios GR, Green MD, Tephly TR (2000). „UDP-glucuronosyltransferases”. Curr. Drug Metab. 1 (2): 143—61. PMID 11465080. doi:10.2174/1389200003339171.
Sánchez-Fructuoso AI, Maestro ML, Calvo N, et al. (2009). „The prevalence of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T and its influence on mycophenolic acid pharmacokinetics in stable renal transplant patients”. Transplant. Proc. 41 (6): 2313—6. PMID 19715905. doi:10.1016/j.transproceed.2009.06.038.
Chu XY, Liang Y, Cai X, et al. (2009). „Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters”. Pharm. Res. 26 (2): 459—68. PMID 19082692. S2CID 24490597. doi:10.1007/s11095-008-9799-5.
Bock KW, Gschaidmeier H, Heel H, et al. (1999). „Functions and transcriptional regulation of PAH-inducible human UDP-glucuronosyltransferases”. Drug Metab. Rev. 31 (2): 411—22. PMID 10335444. doi:10.1081/DMR-100101927.
Saito Y, Sai K, Maekawa K, et al. (2009). „Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 haplotype and its apparent influence on 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation in Japanese”. Drug Metab. Dispos. 37 (2): 272—6. PMID 18981166. S2CID 2886803. doi:10.1124/dmd.108.024208.
Tukey RH, Strassburg CP (2000). „Human UDP-glucuronosyltransferases: metabolism, expression, and disease”. Annu. Rev. Pharmacol. Toxicol. 40: 581—616. PMID 10836148. doi:10.1146/annurev.pharmtox.40.1.581.
Ménard V, Girard H, Harvey M, et al. (2009). „Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population”. Hum. Mutat. 30 (4): 677—87. PMID 19204906. S2CID 6235077. doi:10.1002/humu.20946 .
Cecchin E, Innocenti F, D'Andrea M, et al. (2009). „Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan”. J. Clin. Oncol. 27 (15): 2457—65. PMID 19364970. doi:10.1200/JCO.2008.19.0314 .
Fujiwara R, Nakajima M, Yamamoto T, et al. (2009). „In silico and in vitro approaches to elucidate the thermal stability of human UDP-glucuronosyltransferase (UGT) 1A9”. Drug Metab. Pharmacokinet. 24 (3): 235—44. PMID 19571435. doi:10.2133/dmpk.24.235.
Kadakol A, Ghosh SS, Sappal BS, et al. (2000). „Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype”. Hum. Mutat. 16 (4): 297—306. PMID 11013440. S2CID 24275067. doi:10.1002/1098-1004(200010)16:4<297::AID-HUMU2>3.0.CO;2-Z.
Johnson AD, Kavousi M, Smith AV, et al. (2009). „Genome-wide association meta-analysis for total serum bilirubin levels”. Hum. Mol. Genet. 18 (14): 2700—10. PMC 2701336 . PMID 19414484. doi:10.1093/hmg/ddp202.

[WikiPathways-8] The interactive pathway map can be edited at WikiPathways: „IrinotecanPathway_WP46359”.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000090165 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1910331-4] Wooster R, Sutherland L, Ebner T, Clarke D, Da Cruz e Silva O, Burchell B (септембар 1991). „Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family”. Biochem. J. 278 (2): 465—9. PMC 1151367 . PMID 1910331. doi:10.1042/bj2780465.

[pmid9295054-5] Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (октобар 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001.

[pmid1339448-6] Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (март 1992). „A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini”. J Biol Chem. 267 (5): 3257—61. PMID 1339448. doi:10.1016/S0021-9258(19)50724-4 .

[entrez-7] „Entrez Gene: UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9”.

[9] „Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science”. Journal of Medicinal Chemistry.

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