UGT1A8

UGT1A8
Identifikatori
Alijasi	UGT1A8
Spoljašnji ID	OMIM: 606433 MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A8
Genska lokacija (miš)
Hr.	Chromosome 1 (mouse)
Kraj	88,146,719 bp
Genska ontologija
Molecular function	• transferase activity; • GO:0048551 enzyme inhibitor activity; • retinoic acid binding; • hexosyltransferase activity; • protein homodimerization activity; • glycosyltransferase activity; • glucuronosyltransferase activity; • fatty acid binding; • steroid binding; • protein heterodimerization activity; • enzyme binding; • UDP-glycosyltransferase activity;
Cellular component	• саставни део мембране; • endoplasmic reticulum membrane; • мембрана; • intracellular membrane-bounded organelle; • ендоплазматични ретикулум;
Biological process	• steroid metabolic process; • coumarin metabolic process; • negative regulation of steroid metabolic process; • retinoic acid metabolic process; • negative regulation of cellular glucuronidation; • Metabolizam masnih kiselina; • Glukuronidacija; • flavonoid glucuronidation; • xenobiotic glucuronidation; • flavone metabolic process; • метаболизам; • negative regulation of glucuronosyltransferase activity; • negative regulation of fatty acid metabolic process; • GO:0048553 негативно регулисање каталитичке активности;
	Sources:Amigo / QuickGO
Ortolozi
	54576
	394434
	ENSG00000242366
	ENSMUSG00000090175
	Q9HAW9
	Q62452
	NM_019076
	NM_201644
	NP_061949
	NP_964006
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glukuronoziltransferaza 1-8 je enzim koji je kod ljudi kodiran genom UGT1A8.^[4]^[5]^[6]

Funkcija[уреди | уреди извор]

Ovaj gen kodira UDP-glukuronoziltransferazu, enzim glukuronidacionog puta koji transformiše male lipofilne molekule, kao što su steroidi, bilirubin, hormoni i lekovi, u metabolite koji se mogu izlučiti usled njihove rastovrljivosti u vodi. Ovaj gen je deo kompleksnog lokusa koji kodira nekoliko UDP-glukuronoziltransferaza. Lokus uključuje trinaest jedinstvenih alternativnih prvih eksona praćenih sa četiri zajednička egzona. Četiri alternativna prva egzona se smatraju pseudogenima. Svaki od preostalih devet 5′ eksona može biti spojen sa četiri zajednička eksona, što rezultira u devet proteina sa različitim N-krajevima i identičnim C-krajevima. Svaki prvi egzon kodira mesto vezivanja supstrata i reguliše ga sopstveni promoter. Enzim koji je kodiran ovim genom ima aktivnost glukuronidaze sa mnogim supstratima uključujući kumarine, fenole, antrahinone, flavone i neke opioide.^[4]

Reference[уреди | уреди извор]

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^а ^б Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (март 1992). „A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini”. J Biol Chem. 267 (5): 3257—61. PMID 1339448. doi:10.1016/S0021-9258(19)50724-4 .
^ Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (јун 2002). „Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3”. Pharmacogenetics. 12 (4): 287—97. PMID 12042666. doi:10.1097/00008571-200206000-00004.
^ „Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8”.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1339448-4] а ^б Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (март 1992). „A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini”. J Biol Chem. 267 (5): 3257—61. PMID 1339448. doi:10.1016/S0021-9258(19)50724-4 .

[pmid12042666-5] Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (јун 2002). „Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3”. Pharmacogenetics. 12 (4): 287—97. PMID 12042666. doi:10.1097/00008571-200206000-00004.

[entrez-6] „Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8”.

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