Zanamivir

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Zanamivir
Zanamivir structure.svg
Klinički podaci
Drugs.comMonografija
Način primeneRespiratorno (inhalacija)
Farmakokinetički podaci
Poluvreme eliminacije2,5-5,1 h
IzlučivanjeRenalno
Identifikatori
CAS broj139110-80-8 ДаY
ATC kodJ05AH01 (WHO)
PubChemCID 60855
DrugBankDB00558 ДаY
ChemSpider54842 ДаY
KEGGC08095 ДаY
ChEBICHEBI:50663 ДаY
ChEMBLCHEMBL222813 ДаY
Hemijski podaci
FormulaC12H20N4O7
Molarna masa332,310

Zanamivir je organsko jedinjenje, koje sadrži 12 atoma ugljenika i ima molekulsku masu od 332,310 Da.[1][2][3][4][5][6]

Osobine[уреди]

Osobina Vrednost
Broj akceptora vodonika 10
Broj donora vodonika 7
Broj rotacionih veza 6
Particioni koeficijent[7] (ALogP) -3,4
Rastvorljivost[8] (logS, log(mol/L)) -1,6
Polarna površina[9] (PSA, Å2) 200,7

Reference[уреди]

  1. ^ Meindl P, Bodo G, Palese P, Schulman J, Tuppy H: Inhibition of neuraminidase activity by derivatives of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. Virology. 1974 Apr;58(2):457-63. PMID 4362431
  2. ^ von Itzstein M, Wu WY, Kok GB, Pegg MS, Dyason JC, Jin B, Van Phan T, Smythe ML, White HF, Oliver SW, et al.: Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature. 1993 Jun 3;363(6428):418-23. PMID 8502295
  3. ^ Hata K, Koseki K, Yamaguchi K, Moriya S, Suzuki Y, Yingsakmongkon S, Hirai G, Sodeoka M, von Itzstein M, Miyagi T: Limited Inhibitory Effects of Oseltamivir and Zanamivir on Human Sialidases. Antimicrob Agents Chemother. 2008 Aug 11. PMID 18694948
  4. ^ Sugaya N, Tamura D, Yamazaki M, Ichikawa M, Kawakami C, Kawaoka Y, Mitamura K: Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in children. Clin Infect Dis. 2008 Aug 1;47(3):339-45. PMID 18582202
  5. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  6. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  7. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  8. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  9. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura[уреди]

Spoljašnje veze[уреди]

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