HU-210

Из Википедије, слободне енциклопедије
HU-210
(IUPAC) ime
(6aR,10aR)- 9-(Hidroksimetil)- 6,6-dimetil- 3-(2-metiloktan-2-il)- 6a,7,10,10a-tetrahidrobenzo [c]hromen- 1-ol
Klinički podaci
Identifikatori
CAS broj 112830-95-2
ATC kod nije dodeljen
PubChem[1][2] 9821569
ChemSpider[3] 21106322
ChEMBL[4] CHEMBL70625 YesY
Hemijski podaci
Formula C25H38O3 
Mol. masa 386,567 g/mol
SMILES eMolekuli & PubHem
Sinonimi 1,1-Dimetilheptil- 11-hidroksi- tetrahidrokanabinol
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Plan I kontrolisana supstanca u SAD[5]

HU-210 je sintetički kanabinoid koji je prvi put sintetisan 1988. iz (1R,5S)-mirtenol]]a[6][7][8][9] HU-210 je 100 do 800 puta potentniji od prirodnog THC iz kanabisa i ima duže vreme dejstva.[10] HU-210 je (–)-1,1-dimetilheptil analog 11-hidroksi- Δ8- tetrahidrokanabinola.

Drugi HU kanabinoidi[уреди]

Vidi još[уреди]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ^ Controlled Substances
  6. ^ Mechoulam, R., Lander, N., Breuer, A., Zahalka, J. Synthesis of the Individual, Pharmacologically Distinct, Enantiomers of a Tetrahydrocannabinol Derivative. Tetrahedron: Asymmetry. 1990. Vol 1, No 5. pp 315-318.
  7. ^ Mechoulam, R., et al. (1988). „Enantiomeric cannabinoids: stereospecificity of psychotropic activity“. Experientia 44 (9): 762–764. DOI:10.1007/BF01959156. PMID 3416993. 
  8. ^ Little PJ, Compton DR, Mechoulam R, Martin BR. Stereochemical effects of 11-OH-Δ8-THC-dimethylheptyl in mice and dogs. Pharmacology, Biochemistry, and Behavior. 1989 Mar;32(3):661-666.
  9. ^ Järbe, T.; Hiltunen, A.; Mechoulam, R. (1989). „Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons“. The Journal of Pharmacology and Experimental Therapeutics 250 (3): 1000–1005. PMID 2550611. 
  10. ^ Devane, W. A., et al. (1992). „A novel probe for the cannabinoid receptor“. Journal of Medical Chemistry 35 (11): 2065–2069. DOI:10.1021/jm00089a018. PMID 1317925. 

Spoljašnje veze[уреди]