JWH-015
 | |
| IUPAC ime | |
|---|---|
(2-Metil-1-propil-1H-indol-3-il)-1-naftalenilmetanon | |
| Pravni status | |
| Pravni status |
|
| Identifikatori | |
| CAS broj | 155471-08-2  |
| ATC kod | none |
| PubChem | CID 4273754 |
| Hemijski podaci | |
| Formula | C23H21NO |
| Molarna masa | 327,43 g/mol |
JWH-015 je jedinjenje iz naftoilindolne familije koje deluje kao selektivni kanabinoidni agonist. Njegov afinitet za CB2 receptor je 13,8 nM, dok je njegov afinitet za CB1 383 nM, tako da se skoro 28 puta jače vezuje za CB2 nego CB1.[1] JWH-015 manifestuje slabu CB1 aktivnost, i nije selektivan u istoj meri kao JWH-133.[2] On ima imunomodulatorno dejstvo,[3][4] i CB2 agonisti potencijalno mogu da budu korisni u tretmanu bola i inflamacije.[5][6]
Reference[уреди | уреди извор]
- ^ Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 2000; 60:133-140.
- ^ Marriott, KS; Huffman, JW (2008). „Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor”. Current Topics in Medicinal Chemistry. 8 (3): 187—204. PMID 18289088. doi:10.2174/156802608783498014.
- ^ Ghosh, S; Preet, A; Groopman, JE; Ganju, RK (2006). „Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes”. Molecular immunology. 43 (14): 2169—79. PMID 16503355. doi:10.1016/j.molimm.2006.01.005.
- ^ Montecucco, F; Burger, F; Mach, F; Steffens, S (2008). „CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways”. American journal of physiology. Heart and circulatory physiology. 294 (3): H1145—55. PMID 18178718. doi:10.1152/ajpheart.01328.2007.
- ^ Ehrhart, J; Obregon, D; Mori, T; Hou, H; Sun, N; Bai, Y; Klein, T; Fernandez, F; Tan, J (2005). „Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation”. Journal of neuroinflammation. 2: 29. PMC 1352348
. PMID 16343349. doi:10.1186/1742-2094-2-29.
- ^ Romero-Sandoval, A; Eisenach, JC (2007). „Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision”. Anesthesiology. 106 (4): 787—94. PMID 17413917. doi:10.1097/01.anes.0000264765.33673.6c.
