Kaspofungin

Kaspofungin
Klinički podaci
Drugs.com	Monografija
Način primene	Intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	9-11 h
Izlučivanje	Fekalno 35%, renalno 41%
Identifikatori
CAS broj	179463-17-3
ATC kod	J02AX04 (WHO)
PubChem	CID 2826718
DrugBank	DB00520
ChemSpider	411774
ChEBI	CHEBI:474180
ChEMBL	CHEMBL499808
Hemijski podaci
Formula	C52H88N10O15
Molarna masa	1093,313
	SMILES CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)C1=CC=C(O)C=C1)[C@H](O)CCN; ;
	InChI InChI=1S/C52H88N10O15/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75)/t28?,29?,30-,33-,34+,35+,36-,37+,38-,40+,41+,42+,43+,44+,45+,46+/m1/s1 ; Key:JYIKNQVWKBUSNH-OGZDCFRISA-N ;

Kaspofungin je organsko jedinjenje, koje sadrži 52 atoma ugljenika i ima molekulsku masu od 1093,313 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

Osobine[уреди | уреди извор]

Osobina	Vrednost
Broj akceptora vodonika	18
Broj donora vodonika	16
Broj rotacionih veza	23
Particioni koeficijent^[9] (ALogP)	-2,9
Rastvorljivost^[10] (logS, log(mol/L))	-8,1
Polarna površina^[11] (PSA, Å²)	412,0

Reference[уреди | уреди извор]

^ Letscher-Bru, V.; Herbrecht, R. (2003). „Caspofungin: The first representative of a new antifungal class”. Journal of Antimicrobial Chemotherapy. 51 (3): 513—521. PMID 12615851. doi:10.1093/jac/dkg117.
^ Sucher, A. J.; Chahine, E. B.; Balcer, H. E. (2009-09-01). „Echinocandins: The newest class of antifungals”. The Annals of Pharmacotherapy. 43 (10): 1647—57. PMID 19724014. S2CID 207263606. doi:10.1345/aph.1M237.
^ Morrison, V. A. (октобар 2005). „Caspofungin: An overview”. Expert Review of Anti-Infective Therapy. 3 (5): 697—705. PMID 16207161. S2CID 24716189. doi:10.1586/14787210.3.5.697.
^ McCormack, P. L.; Perry, C. M. (2005). „Caspofungin: A review of its use in the treatment of fungal infections”. Drugs. 65 (14): 2049—68. PMID 16162025. doi:10.2165/00003495-200565140-00009.
^ Morris, M. I.; Villmann, M. (2006-09-15). „Echinocandins in the management of invasive fungal infections, part 1”. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 63 (18): 1693—703. PMID 16960253. doi:10.2146/ajhp050464.p1.
^ Morris, M. I.; Villmann, M. (2006). „Echinocandins in the management of invasive fungal infections, Part 2”. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 63 (19): 1813—1820. PMID 16990627. doi:10.2146/ajhp050464.p2.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. Текст „noedit ” игнорисан (помоћ)
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. Текст „noedit ” игнорисан (помоћ)
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. Текст „noedit ” игнорисан (помоћ)

Literatura[уреди | уреди извор]

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze[уреди | уреди извор]

Caspofungin

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Letscher-Bru, V.; Herbrecht, R. (2003). „Caspofungin: The first representative of a new antifungal class”. Journal of Antimicrobial Chemotherapy. 51 (3): 513—521. PMID 12615851. doi:10.1093/jac/dkg117.

[2] Sucher, A. J.; Chahine, E. B.; Balcer, H. E. (2009-09-01). „Echinocandins: The newest class of antifungals”. The Annals of Pharmacotherapy. 43 (10): 1647—57. PMID 19724014. S2CID 207263606. doi:10.1345/aph.1M237.

[3] Morrison, V. A. (октобар 2005). „Caspofungin: An overview”. Expert Review of Anti-Infective Therapy. 3 (5): 697—705. PMID 16207161. S2CID 24716189. doi:10.1586/14787210.3.5.697.

[4] McCormack, P. L.; Perry, C. M. (2005). „Caspofungin: A review of its use in the treatment of fungal infections”. Drugs. 65 (14): 2049—68. PMID 16162025. doi:10.2165/00003495-200565140-00009.

[5] Morris, M. I.; Villmann, M. (2006-09-15). „Echinocandins in the management of invasive fungal infections, part 1”. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 63 (18): 1693—703. PMID 16960253. doi:10.2146/ajhp050464.p1.

[6] Morris, M. I.; Villmann, M. (2006). „Echinocandins in the management of invasive fungal infections, Part 2”. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 63 (19): 1813—1820. PMID 16990627. doi:10.2146/ajhp050464.p2.

[7] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[8] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. Текст „noedit ” игнорисан (помоћ)

[9] Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.

[10] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. Текст „noedit ” игнорисан (помоћ)

[11] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. Текст „noedit ” игнорисан (помоћ)

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