Somatotropinski receptor

Из Википедије, слободне енциклопедије
Receptor hormona rasta

PDB prikaz baziran na 1a22.
Dostupne strukture
1A22, 1AXI, 1HWG, 1HWH, 1KF9, 2AEW, 3HHR
Identifikatori
Simboli GHR; GHBP
Vanjski ID OMIM600946 MGI95708 HomoloGene134 GeneCards: GHR Gene
Pregled RNK izražavanja
PBB GE GHR 205498 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2690 14600
Ensembl ENSG00000112964 ENSMUSG00000055737
UniProt P10912 P16882
RefSeq (mRNA) NM_000163.4 NM_001048147.1
RefSeq (protein) NP_000154.1 NP_001041612.1
Lokacija (UCSC) Chr 5:
42.42 - 42.72 Mb
Chr 15:
3.32 - 3.58 Mb
PubMed pretraga [1] [2]

Somatotropinski receptor (Receptor hormona rasta) je protein koji je kod ljudi kodiran GHR genom.[1] GHR ontolozi [2] su identifikovani kod većine sisara.

Ovaj protein je transmembranski receptor za hormon rasta. Vezivanje hormona rasta za receptor dovodi do dimerizacije receptora (receptor može da postoji i u obliku nefunkcionalnog dimera [3]) i aktivacija intra- i intercelularne transdukcije signala dovodi do rasta. Čest alternativni alel ovog gena, koji se naziva GHRd3, nema treći ekson. Mutacije tog gena su vezane za sindrom Larona, takođe poznat kao sindrom intenzitivnosti hormona rasta (GHIS). Ovaj poremećaj uzrokuje nizak rast (proporcionalni patuljasti rast).

Interakcije[уреди]

Somatotropinski receptor formira interakcije sa SGTA,[4] PTPN11,[5][6] Janus kinazom 2,[7][8][9] supresorom citokinske signalizacije 1[10] i CISH.[10]

Reference[уреди]

  1. ^ „Entrez Gene: GHR growth hormone receptor“. 
  2. ^ „OrthoMaM phylogenetic marker: GHR coding sequence“. 
  3. ^ Gonzalez, L., L. M. Curto, et al. (2007). "Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver." Growth Horm IGF Res 17(2): 104-112.
  4. ^ Schantl, Julia A; Roza Marcel, De Jong Ad P, Strous Ger J (August 2003). „Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor“. Biochem. J. (England) 373 (Pt 3): 855–63. DOI:10.1042/BJ20021591. ISSN 0264-6021. PMC 1223544. PMID 12735788. 
  5. ^ Stofega, M R; Herrington J, Billestrup N, Carter-Su C (September 2000). „Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B“. Mol. Endocrinol. (UNITED STATES) 14 (9): 1338–50. DOI:10.1210/me.14.9.1338. ISSN 0888-8809. PMID 10976913. 
  6. ^ Moutoussamy, S; Renaudie F, Lago F, Kelly P A, Finidori J (June 1998). „Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins“. J. Biol. Chem. (UNITED STATES) 273 (26): 15906–12. DOI:10.1074/jbc.273.26.15906. ISSN 0021-9258. PMID 9632636. 
  7. ^ Frank, S J; Yi W, Zhao Y, Goldsmith J F, Gilliland G, Jiang J, Sakai I, Kraft A S (June 1995). „Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor“. J. Biol. Chem. (UNITED STATES) 270 (24): 14776–85. DOI:10.1074/jbc.270.24.14776. ISSN 0021-9258. PMID 7540178. 
  8. ^ VanderKuur, J A; Wang X, Zhang L, Campbell G S, Allevato G, Billestrup N, Norstedt G, Carter-Su C (August 1994). „Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase“. J. Biol. Chem. (UNITED STATES) 269 (34): 21709–17. ISSN 0021-9258. PMID 8063815. 
  9. ^ Hellgren, G; Jansson J O, Carlsson L M, Carlsson B (June 1999). „The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver“. Growth Horm. IGF Res. (SCOTLAND) 9 (3): 212–8. DOI:10.1054/ghir.1999.0111. ISSN 1096-6374. PMID 10502458. 
  10. ^ а б Ram, P A; Waxman D J (December 1999). „SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms“. J. Biol. Chem. (UNITED STATES) 274 (50): 35553–61. DOI:10.1074/jbc.274.50.35553. ISSN 0021-9258. PMID 10585430. 

Spoljašnje veze[уреди]