UGT2B17

UGT2B17
Identifikatori
Alijasi	UGT2B17
Spoljašnji ID	OMIM: 601903 MGI: 1919023 HomoloGene: 68144 GeneCards: UGT2B17
Genska lokacija (miš)
Hr.	Chromosome 5 (mouse)
Kraj	87,074,389 bp
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• glycosyltransferase activity; • transferase activity; • glucuronosyltransferase activity; • retinoic acid binding; • hexosyltransferase activity; • UDP-glycosyltransferase activity;
Cellular component	• sastavni deo membrane; • organelle membrane; • endoplasmic reticulum membrane; • membrana; • intracellular membrane-bounded organelle; • endoplazmatični retikulum;
Biological process	• steroid metabolic process; • metabolizam; • Glukuronidacija;
	Sources:Amigo / QuickGO
Ortolozi
	7367
	71773
	ENSG00000197888
	ENSMUSG00000035836
	O75795
	Q8R084
	NM_001077
	NM_152811
	NP_001068
	NP_690024
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glukuronoziltransferaza 2B17 je enzim koji je kod ljudi kodiran genom UGT2B17.^[4]^[5]

UGT2B17 pripada porodici UDP-glukuronoziltransferaza (UGT; EC 2.4.1.17), enzima koji katalizuju prenos glukuronske kiseline iz uridin difosfoglukuronske kiseline na različite supstrate, uključujući steroidne hormone.^[5] Takođe metabolizuje 3-hidroksikotinin, koji je manje zastupljeni metabolit nikotina.^[6]

Reference

^ ^a ^b ^v GRCm38: Ensembl release 89: ENSMUSG00000035836 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Beaulieu M, Levesque E, Hum DW, Belanger A (novembar 1996). „Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids”. J Biol Chem. 271 (37): 22855—62. PMID 8798464. doi:10.1074/jbc.271.37.22855 . CS1 održavanje: Format datuma (veza)
^ ^a ^b „Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17”.
^ Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (oktobar 2010). „Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms”. Cancer Research. 70 (19): 7543—52. PMC 2998997 . PMID 20876810. doi:10.1158/0008-5472.CAN-09-4582. CS1 održavanje: Format datuma (veza)

Literatura

Chung LW, Coffey DS (1978). „Androgen glucuronide. II. Differences in its formation by human normal and benign hyperplastic prostates.”. Investigative Urology. 15 (5): 385—8. PMID 76619.
Moghissi E, Ablan F, Horton R (1984). „Origin of plasma androstanediol glucuronide in men.”. Journal of Clinical Endocrinology & Metabolism. 59 (3): 417—21. PMID 6746859. doi:10.1210/jcem-59-3-417.
Beaulieu M, Lévesque E, Tchernof A (1997). „Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme.”. DNA Cell Biol. 16 (10): 1143—54. PMID 9364925. doi:10.1089/dna.1997.16.1143. Nepoznati parametar |display-author= ignorisan (pomoć)
Collier AC, Ganley NA, Tingle MD (2002). „UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term.”. Biochem. Pharmacol. 63 (3): 409—19. PMID 11853692. doi:10.1016/S0006-2952(01)00890-5. Nepoznati parametar |display-author= ignorisan (pomoć)
Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). „Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.”. Endocr. Res. 30 (4): 717—25. PMID 15666817. S2CID 10971899. doi:10.1081/ERC-200044014.
Lazarus P, Zheng Y, Aaron Runkle E (2006). „Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes.”. Pharmacogenet. Genomics. 15 (11): 769—78. PMID 16220109. S2CID 10171438. doi:10.1097/01.fpc.0000175596.52443.ef. Nepoznati parametar |display-author= ignorisan (pomoć)
Jakobsson J, Ekström L, Inotsume N (2006). „Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism.”. Journal of Clinical Endocrinology & Metabolism. 91 (2): 687—93. PMID 16332934. doi:10.1210/jc.2005-1643 . Nepoznati parametar |display-author= ignorisan (pomoć)
Park J, Chen L, Ratnashinge L (2006). „Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men.”. Cancer Epidemiol. Biomarkers Prev. 15 (8): 1473—8. PMID 16896035. doi:10.1158/1055-9965.EPI-06-0141 . Nepoznati parametar |display-author= ignorisan (pomoć)
Gallagher CJ, Muscat JE, Hicks AN (2007). „The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer.”. Cancer Epidemiol. Biomarkers Prev. 16 (4): 823—8. PMID 17416778. doi:10.1158/1055-9965.EPI-06-0823 . Nepoznati parametar |display-author= ignorisan (pomoć)
Park JY, Tanner JP, Sellers TA (2007). „Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.”. Urology. 70 (2): 374—9. PMID 17826523. doi:10.1016/j.urology.2007.03.001. Nepoznati parametar |display-author= ignorisan (pomoć)
Chouinard S, Barbier O, Bélanger A (2008). „UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.”. J. Biol. Chem. 282 (46): 33466—74. PMID 17848572. doi:10.1074/jbc.M703370200 .

[refGRCm38Ensembl-1] v GRCm38: Ensembl release 89: ENSMUSG00000035836 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8798464-4] Beaulieu M, Levesque E, Hum DW, Belanger A (novembar 1996). „Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids”. J Biol Chem. 271 (37): 22855—62. PMID 8798464. doi:10.1074/jbc.271.37.22855 . CS1 održavanje: Format datuma (veza)

[entrez-5] „Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17”.

[pmid20876810-6] Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (oktobar 2010). „Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms”. Cancer Research. 70 (19): 7543—52. PMC 2998997 . PMID 20876810. doi:10.1158/0008-5472.CAN-09-4582. CS1 održavanje: Format datuma (veza)

[1]

[2]

[3]

[4]

[5]

[6]