KoB-KoM heterodisulfid reduktaza
| KoB-KoM heterodisulfid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.98.1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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KoB-KoM heterodisulfid reduktaza (EC 1.8.98.1, heterodisulfidna reduktaza, rastvorna heterodisulfidna reduktaza) je enzim sa sistematskim imenom koenzim B:koenzim M:metanofenazin oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- koenzim B + koenzim M + metanofenazin N7-[(2-sulfoetil)ditio]heptanoilO3-fosfo-L-treonin + dihidrometanofenazin
Ovaj enzim je prisutan kod metanogenih arheja, posebno kod metanosarcina vrsta. On regeneriše koenzim M i koenzim B nakon dejstva enzima EC 2.8.4.1, koenzim-B sulfoetiltiotransferaze.
Reference[уреди | уреди извор]
- ^ Hedderich, R., Berkessel, A. and Thauer, R.K. (1990). „Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg)”. Eur. J. Biochem. 193: 255—261. PMID 2121478.
- ^ Abken, H.J., Tietze, M., Brodersen, J., Bäumer, S., Beifuss, U. and Deppenmeier, U. (1998). „Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei gol”. J. Bacteriol. 180: 2027—2032. PMID 9555882.
- ^ Simianu, M., Murakami, E., Brewer, J.M. and Ragsdale, S.W. (1998). „Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila”. Biochemistry. 37: 10027—10039. PMID 9665708.
- ^ Murakami, E., Deppenmeier, U. and Ragsdale, S.W. (2001). „Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila”. J. Biol. Chem. 276: 2432—2439. PMID 11034998.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- CoB—CoM+heterodisulfide+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
