D14-sterol reduktaza
| D14-sterol reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.70 | ||||||||
| CAS broj | 69403-07-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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D14-sterol reduktaza (EC 1.3.1.70, D14-sterolna reduktaza) je enzim sa sistematskim imenom 4,4-dimetil-5alfa-holesta-8,24-dien-3beta-ol:NADP+ Delta14-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4,4-dimetil-5alfa-holesta-8,24-dien-3beta-ol + NADP+ 4,4-dimetil-5alfa-holesta-8,14,24-trien-3beta-ol + NADPH + H+
Ovaj enzim deluje na opseg steroida sa 14(15)-dvostrukom vezom.
Reference[уреди | уреди извор]
- ^ Bottema, C.K. & Parks, L.W. (1978). „Δ14-Sterol reductase in Saccharomyces cerevisiae”. Biochim. Biophys. Acta. 531: 301—307. PMID 32908.
- ^ Paik, Y.K., Trzaskos, J.M., Shafice, A. and Gaylor, J.L. (1984). „Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent Δ8,14-steroid 14-reductase”. J. Biol. Chem. 259: 13413—13423. PMID 6444198.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Delta14-sterol+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
