Pirolohinolin-hinon sintaza
| Pirolohinolin-hinon sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.3.11 | ||||||||
| CAS broj | 353484-42-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Pirolohinolin-hinon sintaza (EC 1.3.3.11, PqqC, 6-(2-amino-2-karboksietil)-7,8-diokso-1,2,3,4,5,6,7,8-oktahidrohinolin-2,4-dikarboksilat:kiseonik oksidoreduktaza (ciklizacija)) je enzim sa sistematskim imenom 6-(2-amino-2-karboksietil)-7,8-diokso-1,2,3,4,7,8-heksahidrohinolin-2,4-dikarboksilat:kiseonik oksidoreduktaza (ciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 6-(2-amino-2-karboksietil)-7,8-diokso-1,2,3,4,7,8-heksahidrohinolin-2,4-dikarboksilat + 3 O2 4,5-diokso-4,5-dihidro-1H-pirolo[2,3-f]hinolin-2,7,9-trikarboksilat + 2H2O2 + 2H2O
Za rad ovog enzima je neophodna jedna za sad neophodna komponenta da bi došlo do oslobađanja njegovog produkta.
Reference[уреди | уреди извор]
- ^ Magnusson, O.T., Toyama, H., Saeki, M., Schwarzenbacher, R. and Klinman, J.P. (2004). „The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis”. J. Am. Chem. Soc. 126: 5342—5343. PMID 15113189.
- ^ Magnusson, O.T., Toyama, H., Saeki, M., Rojas, A., Reed, J.C., Liddington, R.C., Klinman, J.P. and Schwarzenbacher, R. (2004). „Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone”. Proc. Natl. Acad. Sci. USA. 101: 7913—7918. PMID 15148379.
- ^ Toyama, H., Chistoserdova, L. and Lidstrom, M.E. (1997). „Sequence analysis of pqq genes required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1 and the purification of a biosynthetic intermediate”. Microbiology. 143: 595—602. PMID 9043136.
- ^ Toyama, H., Fukumoto, H., Saeki, M., Matsushita, K., Adachi, O. and Lidstrom, M.E. (2002). „PqqC/D, which converts a biosynthetic intermediate to pyrroloquinoline quinone”. Biochem. Biophys. Res. Commun. 299: 268—272. PMID 1243798.
- ^ Schwarzenbacher, R., Stenner-Liewen, F., Liewen, H., Reed, J.C. and Liddington, R.C. (2004). „Crystal structure of PqqC from Klebsiella pneumoniae at 2.1 A resolution”. Proteins. 56: 401—403. PMID 15211525.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Pyrroloquinoline-quinone+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
