Dolihil-difosfooligosaharid—protein glikotransferaza
| Dolihil-difosfooligosaharid---protein glikotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.18 | ||||||||
| CAS broj | 75302-32-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Dolihil-difosfooligosaharid---protein glikotransferaza (EC 2.4.99.18, dolihildifosfooligosaharid-protein glikoziltransferaza, asparagin N-glikoziltransferaza, dolihildifosfooligosaharid-protein oligosahariltransferaza, dolihilpirofosfodiacetilhitobioza-protein glikoziltransferaza, oligomanoziltransferaza, oligosaharid transferaza, dolihildifosforiloligosaharid-protein oligosahariltransferaza, dolihil-difosfooligosaharid:protein-L-asparagin oligopolisaharidotransferaza, STT3) je enzim sa sistematskim imenom dolihil-difosfooligosaharid:protein-L-asparagin N-beta-D-oligopolisaharidotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dolihil difosfooligosaharid + [protein]-L-asparagin dolihil difosfat + glikoprotein sa oligosaharidnim lancom vezaim N-beta-D-glikozilnom vezom za protein L-asparagin
Ova reakcija se odvija kod eukariota koji formiraju glikoprotein transferom glukozil-manozil-glukozamin polisaharida na bočni-lanac L-asparaginskog ostatka u sekvenci -Asn-Xaa-Ser- ili -Asn-Xaa-Thr- (Xaa, a ne Pro) u polipeptidnim lancima.
Reference[уреди | уреди извор]
- ^ Das, R.C. & Heath, E.C. (1980). „Dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase; solubilization, purification, and properties”. Proc. Natl. Acad. Sci. USA. 77: 3811—3815. PMID 6933437.
- ^ Song, W., Henquet, M.G., Mentink, R.A., van Dijk, A.J., Cordewener, J.H., Bosch, D., America, A.H. and van der Krol, A.R. (2011). „N-glycoproteomics in plants: perspectives and challenges”. J Proteomics. 74: 1463—1474. PMID 21605711.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Dolichyl-diphosphooligosaccharide---protein+glycotransferase на US National Library of Medicine Medical Subject Headings (MeSH)
