Lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza
| Lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.12 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza (EC 2.4.99.12, KDO transferaza, waaA (gen), kdtA (gen), 3-dezoksi-D-mano-okt-2-ulozonska kiselina transferaza, 3-dezoksi-mano-oktulozonska kiselina transferaza, lipid IVA KDO transferaza) je enzim sa sistematskim imenom CMP-3-dezoksi-D-mano-oct-2-ulozonat:lipid IVA 3-dezoksi-D-mano-okt-2-ulozonat transferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- lipid IVA + CMP-alfa-Kdo alfa-Kdo-(2->6)-lipid IVA + CMP
Ovaj bifunkcionalani enzim iz Escherichia coli prenosi dva 3-dezoksi-D-mano-okt-2-ulozonatna ostataka na lipid IVA (cf. EC 2.4.99.13 [(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza]).
Reference[уреди | уреди извор]
- ^ Belunis, C.J. & Raetz, C.R. (1992). „Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli”. J. Biol. Chem. 267: 9988—9997. PMID 1577828.
- ^ Mamat, U., Schmidt, H., Munoz, E., Lindner, B., Fukase, K., Hanuszkiewicz, A., Wu, J., Meredith, T.C., Woodard, R.W., Hilgenfeld, R., Mesters, J.R. and Holst, O. (2009). „WaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis”. J. Biol. Chem. 284: 22248—22262. PMID 19546212.
- ^ White, K.A., Kaltashov, I.A., Cotter, R.J. and Raetz, C.R. (1997). „A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae”. J. Biol. Chem. 272: 16555—16563. PMID 9195966.
- ^ Lobau, S., Mamat, U., Brabetz, W. and Brade, H. (1995). „Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183”. Mol. Microbiol. 18: 391—399. PMID 8748024.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Lipid+IVA+3-deoxy-D-manno-octulosonic+acid+transferase на US National Library of Medicine Medical Subject Headings (MeSH)
