Nikotinat-nukleotid—dimetilbenzimidazol fosforiboziltransferaza

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Nikotinat-nukleotid—dimetilbenzimidazol fosforiboziltransferaza
EC broj
CAS broj 37277-76-2
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Nikotinat-nukleotid—dimetilbenzimidazol fosforiboziltransferaza (EC, nikotinat mononukleotid-dimetilbenzimidazolna fosforiboziltransferaza, nikotinat ribonukleotid:benzimidazol (adenin) fosforiboziltransferaza, nikotinat-nukleotid:dimetilbenzimidazol fosfo-D-riboziltransferaza, CobT, nikotinat mononukleotid (NaMN):5,6-dimetilbenzimidazol fosforiboziltransferaza) je enzim sa sistematskim imenom nikotinat-nukleotid:5,6-dimetilbenzimidazol fosfo-D-riboziltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

beta-nikotinat D-ribonukleotid + 5,6-dimetilbenzimidazol \rightleftharpoons nikotinat+ alfa-ribazole 5'-fosfat

Ovaj enzim takođe deluje na benzimidazol.


  1. Friedmann, H.C. (1965). „Partial purification and properties of a single displacement trans-N-glycosidase”. J. Biol. Chem. 240: 413-418. PMID 14253445. 
  2. Friedmann, H.C. and Fyfe, J.A. (1969). „Pseudovitamin B12 biosynthesis. Enzymatic formation of a new adenylic acid, 7-α-D-ribofuranosyladenine 5′-phosphate”. J. Biol. Chem. 244: 1667-1671. PMID 5780835. 
  3. Fyfe, J.A. and Friedmann, H.C. (1969). „Vitamin B12 biosynthesis. Enzyme studies on the formation of the α-glycosidic nucleotide precursor”. J. Biol. Chem. 244: 1659-1666. PMID 4238408. 
  4. Cameron, B., Blanche, F., Rouyez, M.C., Bisch, D., Famechon, A., Couder, M., Cauchois, L., Thibaut, D., Debussche, L. and Crouzet, J. (1991). „Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5′-phosphate) synthase”. J. Bacteriol. 173: 6066-6073. PMID 1917841. 
  5. Cheong, C.G., Escalante-Semerena, J.C. and Rayment, I. (2001). „Structural investigation of the biosynthesis of alternative lower ligands for cobamides by nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella enterica”. J. Biol. Chem. 276: 37612-37620. PMID 11441022. 
  6. Cheong, C.G., Escalante-Semerena, J.C. and Rayment, I. (2002). „Capture of a labile substrate by expulsion of water molecules from the active site of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enterica”. J. Biol. Chem. 277: 41120-41127. PMID 12101181. 


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