Синдром

Синдром, етимолошки од Грчке речи (грч. συνδρομή - успети заједно), (лат. syndroma), је у клиничкој медицини, психијатрији и клиничкој психологији, скуп међусобно повезаних симптома који чине једну кохерентну нозолошку целину (нпр. анксиозно-депресивни синдром, параноидни синдром, Корсаковљев синдром). У психологији личности и социјалној психологији, синдром означава склоп емпиријски и смисаоно повезаних црта личности које се јављају заједно у некој личности и образују одређену релативно чврсту структуру. Синдром у медицини обично чини најмање три симтома, међусобно повезаних који се увек јављају заједно (тзв. клинички тријас симптома), али их може бити и више.

The word derives from the Greek σύνδρομον, meaning "concurrence". When a syndrome is paired with a definite cause this becomes a disease. In some instances, a syndrome is so closely linked with a pathogenesis or cause that the words syndrome, disease, and disorder end up being used interchangeably for them. This substitution of terminology often confuses the reality and meaning of medical diagnoses. This is especially true of inherited syndromes. About one third of all phenotypes that are listed in OMIM are described as dysmorphic, which usually refers to the facial gestalt. For example, Down syndrome, Wolf–Hirschhorn syndrome, and Andersen–Tawil syndrome are disorders with known pathogeneses, so each is more than just a set of signs and symptoms, despite the syndrome nomenclature. In other instances, a syndrome is not specific to only one disease. For example, toxic shock syndrome can be caused by various toxins; premotor syndrome can be caused by various brain lesions; and premenstrual syndrome is not a disease but simply a set of symptoms.

Подсиндроматски

When there are a number of symptoms suggesting a particular disease or condition but does not meet the defined criteria used to make a diagnosis of that disease or condition. This can be a bit subjective because it is ultimately up to the clinician to make the diagnosis. This could be because it has not advanced to the level or passed a threshold or just similar symptoms cause by other issues. Subclinical is synonymous since one of its definitions is "where some criteria are met but not enough to achieve clinical status"; but subclinical is not always interchangeable since it can also mean "not detectable or producing effects that are not detectable by the usual clinical tests"; i.e., asymptomatic.

Употреба

General medicine

In medicine, a broad definition of syndrome is used, which describes a collection of symptoms and findings without necessarily tying them to a single identifiable pathogenesis. Examples of infectious syndromes include encephalitis and hepatitis, which can both have several different infectious causes. The more specific definition employed in medical genetics describes a subset of all medical syndromes.

Psychiatry and psychopathology

Psychiatric syndromes often called psychopathological syndromes (psychopathology refers both to psychic dysfunctions occurring in mental disorders, and the study of the origin, diagnosis, development, and treatment of mental disorders).

In Russia those psychopathological syndromes are used in modern clinical practice and described in psychiatric literature in the details: asthenic syndrome, obsessive syndrome, emotional syndromes (for example, manic syndrome, depressive syndrome), Cotard's syndrome, catatonic syndrome, hebephrenic syndrome, delusional and hallucinatory syndromes (for example, paranoid syndrome, paranoid-hallucinatory syndrome, Kandinsky-Clérambault's syndrome also known as syndrome of psychic automatism, hallucinosis), paraphrenic syndrome, psychopathic syndromes (includes all personality disorders), clouding of consciousness syndromes (for example, twilight clouding of consciousness, amential syndrome also known as amentia, delirious syndrome, stunned consciousness syndrome, oneiroid syndrome), hysteric syndrome, neurotic syndrome, Korsakoff's syndrome, hypochondriacal syndrome, paranoiac syndrome, senestopathic syndrome, encephalopathic syndrome.

Some examples of psychopathological syndromes used in modern Germany are psychoorganic syndrome, depressive syndrome, paranoid-hallucinatory syndrome, obsessive-compulsive syndrome, autonomic syndrome, hostility syndrome, manic syndrome, apathy syndrome.

Münchausen syndrome, Ganser syndrome, neuroleptic-induced deficit syndrome, olfactory reference syndrome are also well-known.

History

The most important psychopathological syndromes were classified into three groups ranked in order of severity by German psychiatrist Emil Kraepelin (1856—1926). The first group, which includes the mild disorders, consists of five syndromes: emotional, paranoid, hysterical, delirious, and impulsive. The second, intermediate, group includes two syndromes: schizophrenic syndrome and speech-hallucinatory syndrome. The third includes the most severe disorders, and consists of three syndromes: epileptic, oligophrenic and dementia. In Kraepelin's era, epilepsy was viewed as a mental illness; Karl Jaspers also considered "genuine epilepsy" a "psychosis", and described "the three major psychoses" as schizophrenia, epilepsy, and manic-depressive illness.

Medical genetics

In the field of medical genetics, the term "syndrome" is traditionally only used when the underlying genetic cause is known. Thus, trisomy 21 is commonly known as Down syndrome.

Until 2005, CHARGE syndrome was most frequently referred to as "CHARGE association". When the major causative gene (CHD7) for the condition was discovered, the name was changed. The consensus underlying cause of VACTERL association has not been determined, and thus it is not commonly referred to as a "syndrome".

Other fields

In biology, "syndrome" is used in a more general sense to describe characteristic sets of features in various contexts. Examples include behavioral syndromes, as well as pollination syndromes and seed dispersal syndromes.

In orbital mechanics and astronomy, Kessler syndrome refers to the effect where the density of objects in low Earth orbit (LEO) is high enough that collisions between objects could cause a cascade in which each collision generates space debris that increases the likelihood of further collisions.

In quantum error correction theory syndromes correspond to errors in code words which are determined with syndrome measurements, which only collapse the state on an error state, so that the error can be corrected without affecting the quantum information stored in the code words.

Именовање

There is no set common convention for the naming of newly identified syndromes. In the past, syndromes were often named after the physician or scientist who identified and described the condition in an initial publication, these are referred to as "eponymous syndromes". In some cases, diseases are named after the patient who initially presents with symptoms, or their home town (Stockholm syndrome). There have been isolated cases of patients being eager to have their syndromes named after them, while their physicians are hesitant. When a syndrome is named after a person, there is some difference of opinion as to whether it should take the possessive form or not (e.g. Down syndrome vs. Down's syndrome). North American usage has tended to favor the non-possessive form, while European references often use the possessive. Even in Europe, there has been a trend away from the possessive form, over the period between 1970 and 2008.

Историја

Avicenna, in The Canon of Medicine (published 1025), pioneered the idea of a syndrome in the diagnosis of specific diseases. The concept of a medical syndrome was further developed in the 17th century by Thomas Sydenham.

Примери означавања синдрома

Честа је појава, у медицинској пракси, да се поједини синдроми означавају према ауторима који су их открили (описали), али и према факторима који су их изазвали, најчешћој локализацији итд. Ево најчешћих примера додељивања назива синдрому;

• према презимену или имену аутора: Даунов синдром, Корсаковљев синдром, Паркинсонов синдром, Скуминљев синдром
• према узроку: Краш синдром, Синдром апстиненције
• према патогенетском фактору: компресивни синдром, думпинг синдром
• према доминатном симптому: синдром страха, Хемолитички уремијски синдром
• према типичној анатомској локализацији: цервикални (вратни) синдром,
• према патоанатомском налазу: синдром склерозе мозга

Галерија синдрома

• 
  Дете са Дауновим синдромом
• 
  Схема ауторецесивног наслеђивања у Блумовом синдрому
• 
  Лофлеров синдром
• 
  Чарг-Штраусов синдром

Литература

• Овај чланак или његов део изворно је преузет из Речника социјалног рада Ивана Видановића уз одобрење аутора.
• Mofenson HC, Greensher J (1970). „The nontoxic ingestion”. Pediatric Clinics of North America. 17 (3): 583—90. PMID 5491430. doi:10.1016/s0031-3955(16)32453-1. 
• Goldfrank, Flomenbaum; Lewin, Weisman; Howland, Hoffman (1998). Goldfrank's Toxicologic Emergencies (6th изд.). Stamford, Connecticut: Appleton & Lange. ISBN 0-8385-3148-2. 
• Stead, LG; Stead, SM; Kaufman, MS (2006). First Aid for the Emergency Medicine Clerkship (2nd изд.). McGraw-Hill. стр. 395–6. ISBN 0-07-144873-X. 
• Nelson, Lewis H.; Flomenbaum, Neal; Goldfrank, Lewis R.; Hoffman, Robert Louis; Howland, Mary Deems; Neal A. Lewin (2006). Goldfrank's toxicologic emergencies. New York: McGraw-Hill, Medical Pub. Division. ISBN 0-07-143763-0. 

Спољашње везе

• „Who Named It“, речник медицинских феномена
• Апстиненцијални синдром опијатских зависника