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FUT7

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FUT7
Identifikatori
AlijasiFUT7
Spoljašnji IDOMIM: 602030 MGI: 107692 HomoloGene: 3296 GeneCards: FUT7
Obrazac RNK izražavanja


More reference expression data
Ortolozi
VrsteČovekMiš
Entrez

2529

14347

Ensembl

ENSG00000180549

ENSMUSG00000036587

UniProt

Q11130

Q11131

RefSeq (mRNA)

NM_004479

RefSeq (protein)

NP_004470

Location (UCSC)n/aChr 2: 25.31 – 25.32 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Fukoziltransferaza 7 je enzim koji je kod ljudi kodiran genom FUT7.[4][5][6]

Funkcija[uredi | uredi izvor]

Sijalil Luis x oligosaharidna determinanta je suštinska komponenta leukocitnih kontrareceptora za adhezije leukocita posredovana E-selektinom (MIM 131210) i P-selektinom (MIM 173610). Ovaj molekul oligosaharida se prikazuje na površinama granulocita, monocita i prirodnih ćelija ubica. Formiranje adhezije leukocita za ove selektine je rani i važan korak u procesu koji na kraju omogućava leukocitima da napuste vaskularno stablo i postanu regrutovani u limfoidna tkiva i mesta upale.[6]

Reference[uredi | uredi izvor]

  1. ^ a b v GRCm38: Ensembl release 89: ENSMUSG00000036587 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB (jun 1994). „Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant”. The Journal of Biological Chemistry. 269 (24): 16789—94. PMID 8207002. doi:10.1016/S0021-9258(19)89461-9 Slobodan pristup. 
  5. ^ Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T (maj 1994). „Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes”. The Journal of Biological Chemistry. 269 (20): 14730—7. PMID 8182079. doi:10.1016/S0021-9258(17)36686-3 Slobodan pristup. 
  6. ^ a b „Entrez Gene: FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)”. 

Literatura[uredi | uredi izvor]

  • Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB (avgust 1994). „Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant”. The Journal of Biological Chemistry. 269 (32): 20806. PMID 8051184. doi:10.1016/S0021-9258(17)32066-5 Slobodan pristup. 
  • Smith PL, Gersten KM, Petryniak B, Kelly RJ, Rogers C, Natsuka Y, Alford JA, Scheidegger EP, Natsuka S, Lowe JB (april 1996). „Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands”. The Journal of Biological Chemistry. 271 (14): 8250—9. PMID 8626519. doi:10.1074/jbc.271.14.8250 Slobodan pristup. 
  • Le Marer N, Palcic MM, Clarke JL, Davies D, Skacel PO (april 1997). „Developmental regulation of alpha 1,3-fucosyltransferase expression in CD34 positive progenitors and maturing myeloid cells isolated from normal human bone marrow”. Glycobiology. 7 (3): 357—65. PMID 9147044. doi:10.1093/glycob/7.3.357 Slobodan pristup. 
  • Mas E, Pasqualini E, Caillol N, El Battari A, Crotte C, Lombardo D, Sadoulet MO (jun 1998). „Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines”. Glycobiology. 8 (6): 605—13. PMID 9592127. doi:10.1093/glycob/8.6.605 Slobodan pristup. 
  • Bengtson P, Larson C, Lundblad A, Larson G, Påhlsson P (avgust 2001). „Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene”. The Journal of Biological Chemistry. 276 (34): 31575—82. PMID 11404359. doi:10.1074/jbc.M104165200 Slobodan pristup. 
  • de Vries T, Yen TY, Joshi RK, Storm J, van Den Eijnden DH, Knegtel RM, Bunschoten H, Joziasse DH, Macher BA (maj 2001). „Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures”. Glycobiology. 11 (5): 423—32. PMID 11425803. doi:10.1093/glycob/11.5.423 Slobodan pristup. 
  • Roos C, Kolmer M, Mattila P, Renkonen R (februar 2002). „Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism”. The Journal of Biological Chemistry. 277 (5): 3168—75. PMID 11698403. doi:10.1074/jbc.M107927200 Slobodan pristup. 
  • Zerfaoui M, Fukuda M, Langlet C, Mathieu S, Suzuki M, Lombardo D, El-Battari A (januar 2002). „The cytosolic and transmembrane domains of the beta 1,6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant”. Glycobiology. 12 (1): 15—24. PMID 11825883. doi:10.1093/glycob/12.1.15 Slobodan pristup. 
  • Hiraiwa N, Yabuta T, Yoritomi K, Hiraiwa M, Tanaka Y, Suzuki T, Yoshida M, Kannagi R (maj 2003). „Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element”. Blood. 101 (9): 3615—21. PMID 12506041. doi:10.1182/blood-2002-07-2301 Slobodan pristup. 
  • Zisoulis DG, Kansas GS (septembar 2004). „H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells”. The Journal of Biological Chemistry. 279 (38): 39495—504. PMID 15262995. doi:10.1074/jbc.M407904200 Slobodan pristup. 
  • Miyashiro M, Furuya S, Fujishige K, Sugita T (novembar 2004). „Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII”. Biochemical and Biophysical Research Communications. 324 (1): 98—107. PMID 15464988. doi:10.1016/j.bbrc.2004.09.025. 
  • Martinez M, Joffraud M, Giraud S, Baïsse B, Bernimoulin MP, Schapira M, Spertini O (februar 2005). „Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII”. The Journal of Biological Chemistry. 280 (7): 5378—90. PMID 15579466. doi:10.1074/jbc.M410899200 Slobodan pristup. 
  • Prorok-Hamon M, Notel F, Mathieu S, Langlet C, Fukuda M, El-Battari A (novembar 2005). „N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding”. The Biochemical Journal. 391 (Pt 3): 491—502. PMC 1276950 Slobodan pristup. PMID 15926890. doi:10.1042/BJ20050344. 
  • Brown V, Brown RA, Ozinsky A, Hesselberth JR, Fields S (mart 2006). „Binding specificity of Toll-like receptor cytoplasmic domains”. European Journal of Immunology. 36 (3): 742—53. PMC 2762736 Slobodan pristup. PMID 16482509. doi:10.1002/eji.200535158. 
  • Wang QY, Zhang Y, Chen HJ, Shen ZH, Chen HL (januar 2007). „Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway”. The FEBS Journal. 274 (2): 526—38. PMID 17229154. S2CID 25250189. doi:10.1111/j.1742-4658.2006.05599.x Slobodan pristup. 


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