NPR3

Natriuretski peptidni receptor C/guanilat ciklaza C (atrionatriuretski peptidni receptor C)
Natriuretski peptidni receptor C/guanilat ciklaza C (atrionatriuretski peptidni receptor C)
	PDB prikaz baziran na 1yk0.
Dostupne strukture
	1yk0, 1jdp, 1yk1, 1jdn
Identifikatori
Simboli	NPR3; GUCY2B; NPRC; ANPRC
Vanjski ID	OMIM: 108962 MGI: 97373 HomoloGene: 699 GeneCards: NPR3 Gene
Ontologija gena
Molekularna funkcija	• aktivnost peptidnog receptora, G protein spregnutog; • vezivanje jona hlorida; • aktivnost natriuretskog peptidnog receptora; • receptorska aktivnost;
Celularna komponenta	• membrana; • integralno sa membranom; • membranska frakcija;
Biološki proces	• inhibicija aktivnosti adenilat ciklaze G-proteinskom signalizacijom; • regulacija krvnog pritiska; • razvoj skeletalnog sistema;
Ortolozi
Vrsta	Čovek
Entrez	4883
Ensembl	ENSG00000113389
UniProt	P17342
RefSeq (mRNA)	NM_000908
RefSeq (protein)	NP_000899
Lokacija (UCSC)	Chr 5:; 32.71 - 32.79 Mb
PubMed pretraga	[1]

Natriuretski peptidni receptor C (atrionatriuretski peptidni receptor C, NPR3) je receptor atrijalnog natriuretskog peptida. Ovaj receptor je kod čoveka kodiran NPR3 genom.^[1]

Funkcija[уреди | уреди извор]

Familija natriuretskih peptida vrši brojne vaskularne, renalne, i endokrine funkcije održavanja krvnog pritiska i zapremine ekstracelularnog fluida. Ta dejstva su posredovana specifičnim vezivanjem peptida za receptore na površini ćelija u vaskulaturnom sistemu, bubrezima, adrenalnoj žlezdi, i mozgu.^[1]

Reference[уреди | уреди извор]

^ ^а ^б „Entrez Gene: NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)”.

Literatura[уреди | уреди извор]

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He Xl; Chow Dc; Martick MM; Garcia KC (2001). „Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone.”. Science. 293 (5535): 1657—62. PMID 11533490. doi:10.1126/science.1062246.
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Aoi N; Soma M; Nakayama T; et al. (2004). „Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension.”. Hypertens. Res. 27 (10): 711—6. PMID 15785005. doi:10.1291/hypres.27.711.
Anand-Srivastava MB (2005). „Natriuretic peptide receptor-C signaling and regulation.”. Peptides. 26 (6): 1044—59. PMID 15911072. doi:10.1016/j.peptides.2004.09.023.
Estrada K; Krawczak M; Schreiber S; et al. (2009). „A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.”. Hum. Mol. Genet. 18 (18): 3516—24. PMC 2729669 . PMID 19570815. doi:10.1093/hmg/ddp296.
Burgess MD; Moore KD; Carter GM; et al. (2009). „C-type natriuretic peptide receptor expression in pancreatic alpha cells.”. Histochem. Cell Biol. 132 (1): 95—103. PMID 19352691. doi:10.1007/s00418-009-0591-3.
Vassalle C; Andreassi MG; Prontera C; et al. (2007). „Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure.”. Clin. Chem. 53 (11): 1886—90. PMID 17890443. doi:10.1373/clinchem.2007.088302.
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He XL, Dukkipati A, Wang X, Garcia KC (2005). „A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C.”. Peptides. 26 (6): 1035—43. PMID 15911071. doi:10.1016/j.peptides.2004.08.035.