Natriuretski peptid

Natriuretski peptid je peptid koji indukuje natriurezu (ispuštanje natrijuma putem urina).

Tipovi

Poznato je nekoliko tipova natriuretskih peptida:

Atrijalni natriuretski peptid^[1]^[2]^[3]: srčana pretkomora
Moždani natriuretski peptid^[4]: srčana komora kod ljudi, mozak kod svinja
C-tip natriuretskog peptida^[5]^[6]^[7]
Dendroaspis natriuretski peptid^[8]

Natriuretski peptidi u postavljanju dijagnoze

U postavljanju dijagnoze srčane insuficijencije određivanje koncentracije natriuretskih peptida ima veliki značaj jer su simptomi bolesti nespecifični a ehokardiogram može biti nedostupan.^[9]

Nivo natriuretskih peptida raste sa starenjem, može biti snižen kod gojaznih, a normalne vrednosti kod nelečenih bolesnika isključuju postojanje značajnog srčanog oboljenja.^[10]

Kod bolesnika sa novonastalom ili pogoršanjem srčane insufcijencije, granična vrednost N terminalnog pro B natriuretski peptid je 300 pg/ml, a za moždani natriuretski peptid100 pg/ml

Kod hroničnog oblika srčane insuficijencije, granična vrednost za N terminalnog pro B natriuretski peptid je 125 pg/ml, a za moždani natriuretski peptid 35 pg/Ml. U drugoj grupi bolesnika senzitivnost i specifičnost navedenih testova je manja.^[9]^[10]

Reference

^ Widmaier, Eric P.; Hershel Raff; Kevin T. Strang (2008). Vander's Human Physiology, 11th Ed. McGraw-Hill. стр. 291,509–10. ISBN 978-0-07-304962-5.
^ Potter LR, Yoder AR, Flora DR, Antos LK, Dickey DM (2009). „Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications”. Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 191 (191): 341—66. ISBN 978-3-540-68960-7. PMID 19089336. doi:10.1007/978-3-540-68964-5_15.
^ Addicks K, Forssmann WG, Henkel H, Holthausen U, Menz V, Rippegather G, Ziskoven D (1989). „Calcium-calmodulin antagonists Influences the release of cardiodilatin/ANP from atrial cardiocytes”. Ур.: Wambach G, Kaufmann W. Endocrinology of the heart. Berlin: Springer-Verlag. ISBN 978-0-387-51409-3.
^ Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1
^ „Entrez Gene: NPPC natriuretic peptide precursor C”.
^ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (1993). „C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid”. Brain Res. 612 (1–2): 104—9. PMID 8330189. doi:10.1016/0006-8993(93)91649-D.
^ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (1994). „Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)”. Genomics. 24 (2): 383—7. PMID 7698765. doi:10.1006/geno.1994.1633.
^ Lisy O, Lainchbury JG, Leskinen H, Burnett JC (2001). „Therapeutic actions of a new synthetic vasoactive and natriuretic peptide, dendroaspis natriuretic peptide, in experimental severe congestive heart failure”. Hypertension. 37: 1089—94.
^ ^а ^б Dokainish, H.; Nguyen, J. S.; Bobek, J.; Goswami, R.; Lakkis, N. M. (2011-09-01). „Assessment of the American Society of Echocardiography-European Association of Echocardiography guidelines for diastolic function in patients with depressed ejection fraction: an echocardiographic and invasive haemodynamic study”. European Journal of Echocardiography. 12 (11): 857—864. ISSN 1525-2167. doi:10.1093/ejechocard/jer157.
^ ^а ^б Ewald B, Ewald D, Thakkinstian A, Attia J (2008). „Meta-analysis of B type natriuretic peptide and Nterminal pro B natriuretic peptide in the diagnosis of clinical heart failure and population screening for left ventricular systolic dysfunction”. Intern Med J. 38: 101—113. .

Spoljašnje veze

Natriuretic+peptides на US National Library of Medicine Medical Subject Headings (MeSH)

[Widmaier-1] Widmaier, Eric P.; Hershel Raff; Kevin T. Strang (2008). Vander's Human Physiology, 11th Ed. McGraw-Hill. стр. 291,509–10. ISBN 978-0-07-304962-5.

[pmid19089336-2] Potter LR, Yoder AR, Flora DR, Antos LK, Dickey DM (2009). „Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications”. Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 191 (191): 341—66. ISBN 978-3-540-68960-7. PMID 19089336. doi:10.1007/978-3-540-68964-5_15.

[isbn0-387-51409-0-3] Addicks K, Forssmann WG, Henkel H, Holthausen U, Menz V, Rippegather G, Ziskoven D (1989). „Calcium-calmodulin antagonists Influences the release of cardiodilatin/ANP from atrial cardiocytes”. Ур.: Wambach G, Kaufmann W. Endocrinology of the heart. Berlin: Springer-Verlag. ISBN 978-0-387-51409-3.

[4] Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1

[entrez-5] „Entrez Gene: NPPC natriuretic peptide precursor C”.

[pmid8330189-6] Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (1993). „C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid”. Brain Res. 612 (1–2): 104—9. PMID 8330189. doi:10.1016/0006-8993(93)91649-D.

[pmid7698765-7] Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (1994). „Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)”. Genomics. 24 (2): 383—7. PMID 7698765. doi:10.1006/geno.1994.1633.

[8] Lisy O, Lainchbury JG, Leskinen H, Burnett JC (2001). „Therapeutic actions of a new synthetic vasoactive and natriuretic peptide, dendroaspis natriuretic peptide, in experimental severe congestive heart failure”. Hypertension. 37: 1089—94.

[:0-9] а ^б Dokainish, H.; Nguyen, J. S.; Bobek, J.; Goswami, R.; Lakkis, N. M. (2011-09-01). „Assessment of the American Society of Echocardiography-European Association of Echocardiography guidelines for diastolic function in patients with depressed ejection fraction: an echocardiographic and invasive haemodynamic study”. European Journal of Echocardiography. 12 (11): 857—864. ISSN 1525-2167. doi:10.1093/ejechocard/jer157.

[:1-10] а ^б Ewald B, Ewald D, Thakkinstian A, Attia J (2008). „Meta-analysis of B type natriuretic peptide and Nterminal pro B natriuretic peptide in the diagnosis of clinical heart failure and population screening for left ventricular systolic dysfunction”. Intern Med J. 38: 101—113. .

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