FSH-receptor

Из Википедије, слободне енциклопедије
Struktura interakcije FSH i FSH-receptora
PDB prikaz baziran na 1xwd.
Dostupne strukture
1xwd
Identifikatori
Simboli FSHR; FSHRO; LGR1; MGC141667; MGC141668; ODG1
Vanjski ID OMIM136435 MGI95583 HomoloGene117 IUPHAR: FSH GeneCards: FSHR Gene
Pregled RNK izražavanja
PBB GE FSHR 211201 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2492 14309
Ensembl ENSG00000170820 ENSMUSG00000032937
UniProt P23945 P35378
RefSeq (mRNA) NM_000145 NM_013523
RefSeq (protein) NP_000136 NP_038551
Lokacija (UCSC) Chr 2:
49.04 - 49.24 Mb
Chr 17:
88.89 - 89.11 Mb
PubMed pretraga [1] [2]

Folikulostimulišući hormonski receptor ili FSH-receptor (FSHR) je transmembranski receptor koji interaguje sa Folikulostimulišućim hormonom (FSH). On je G protein-spregnuti receptor (GPCR). Njegova aktivacija je neophodna za FSH hormonsko funkcionisanje. FSHR receptori su nađeni u jajnicima, testisima, i uterusu.

FSHR gen[уреди]

FSHR gen se nalazi na hromozomu 2 p21 kod čoveka. FSHR genska sekvenca se sastoji od oko 2,080 nukleotida.[1]

Struktura receptora[уреди]

Struktura G protein-spregnutog receptora kao što je FSHR sa sedam transmembranskih α-heliksa

FSHR se sastoji od 695 aminokiselina, i ima molekulsku masu od oko 76 kDa.[1] Poput drugih GPCR receptora, FSH-receptor poseduje sedam domena (transmembranskih heliksa), svaki od kojih premoštava membranu.

  • Transmembranski domen sadrži dva visoko očuvana cisteinska ostatka koji formiraju disulfidnu vezs čime se stabilizuje struktura receptora. Visoko konzervirani Asp-Arg-Tyr triplet je prisutan i verovatno učestvuje u prenosu signala.

Reference[уреди]

  1. 1,0 1,1 Simoni M, Gromoll J, Nieschlag E (1997). „The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology”. Endocr. Rev. 18 (6): 739—73. doi:10.1210/er.18.6.739. PMID 9408742. 

Literatura[уреди]

  • de la Chapelle A (1993). „Disease gene mapping in isolated human populations: the example of Finland.”. J. Med. Genet. 30 (10): 857—65. doi:10.1136/jmg.30.10.857. PMC 1016570. PMID 8230163. 
  • Amsterdam A, Hanoch T, Dantes A; et al. (2003). „Mechanisms of gonadotropin desensitization.”. Mol. Cell. Endocrinol. 187 (1-2): 69—74. doi:10.1016/S0303-7207(01)00701-8. PMID 11988313. 
  • Simoni M, Nieschlag E, Gromoll J (2003). „Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction.”. Hum. Reprod. Update 8 (5): 413—21. doi:10.1093/humupd/8.5.413. PMID 12398222. 
  • Delbaere A, Smits G, Olatunbosun O; et al. (2004). „New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?”. Hum. Reprod. 19 (3): 486—9. doi:10.1093/humrep/deh124. PMC 2891954. PMID 14998941. 
  • Bose CK (2005). „Role of nerve growth factor and FSH receptor in epithelial ovarian cancer.”. Reprod. Biomed. Online 11 (2): 194—7. doi:10.1016/S1472-6483(10)60958-3. PMID 16168216. 
  • Wunsch A, Sonntag B, Simoni M (2007). „Polymorphism of the FSH receptor and ovarian response to FSH.”. Ann. Endocrinol. (Paris) 68 (2-3): 160—6. doi:10.1016/j.ando.2007.04.006. PMID 17544358. 
  • Kelton CA, Cheng SV, Nugent NP; et al. (1993). „The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.”. Mol. Cell. Endocrinol. 89 (1-2): 141—51. doi:10.1016/0303-7207(92)90220-Z. PMID 1301382. 
  • Tilly JL, Aihara T, Nishimori K; et al. (1992). „Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.”. Endocrinology 131 (2): 799—806. doi:10.1210/en.131.2.799. PMID 1322283. 
  • Gromoll J, Gudermann T, Nieschlag E (1992). „Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.”. Biochem. Biophys. Res. Commun. 188 (3): 1077—83. doi:10.1016/0006-291X(92)91341-M. PMID 1359889. 
  • Minegishi T, Nakamura K, Takakura Y; et al. (1991). „Cloning and sequencing of human FSH receptor cDNA.”. Biochem. Biophys. Res. Commun. 175 (3): 1125—30. doi:10.1016/0006-291X(91)91682-3. PMID 1709010. 
  • Gromoll J, Ried T, Holtgreve-Grez H; et al. (1994). „Localization of the human FSH receptor to chromosome 2 p21 using a genomic probe comprising exon 10.”. J. Mol. Endocrinol. 12 (3): 265—71. doi:10.1677/jme.0.0120265. PMID 7916967. 
  • Gromoll J, Dankbar B, Gudermann T (1994). „Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.”. Mol. Cell. Endocrinol. 102 (1-2): 93—102. doi:10.1016/0303-7207(94)90102-3. PMID 7926278. 
  • Rousseau-Merck MF, Atger M, Loosfelt H; et al. (1993). „The chromosomal localization of the human follicle-stimulating hormone receptor gene (FSHR) on 2p21-p16 is similar to that of the luteinizing hormone receptor gene.”. Genomics 15 (1): 222—4. doi:10.1006/geno.1993.1041. PMID 8432542. 
  • Jiang X, Dreano M, Buckler DR; et al. (1996). „Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.”. Structure 3 (12): 1341—53. doi:10.1016/S0969-2126(01)00272-6. PMID 8747461. 
  • Aittomäki K, Herva R, Stenman UH; et al. (1996). „Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene.”. J. Clin. Endocrinol. Metab. 81 (10): 3722—6. doi:10.1210/jc.81.10.3722. PMID 8855829. 
  • Tapanainen JS, Aittomäki K, Min J; et al. (1997). „Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility.”. Nat. Genet. 15 (2): 205—6. doi:10.1038/ng0297-205. PMID 9020851. 
  • Kotlar TJ, Young RH, Albanese C; et al. (1997). „A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.”. J. Clin. Endocrinol. Metab. 82 (4): 1020—6. doi:10.1210/jc.82.4.1020. PMID 9100567. 

Vidi još[уреди]

Spoljašnje veze[уреди]