A-1,6-manozil-glikoprotein 6-b-N-acetilglukozaminiltransferaza
| A-1,6-manozil-glikoprotein 6-b-N-acetilglukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.155 | ||||||||
| CAS broj | 83588-90-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
A-1,6-manozil-glikoprotein 6-b-N-acetilglukozaminiltransferaza (EC 2.4.1.155, N-acetilglukozaminiltransferaza V, alfa-manozid beta-1,6-N-acetilglukozaminiltransferaza, uridin difosfoacetilglukozamin-alfa-manozid beta1->6-acetilglukozaminiltransferaza, UDP-N-acetilglukozamin:alfa-manozid-beta1,6 N-acetilglukozaminiltransferaza, alfa-1,3(6)-manozilglikoprotein beta-1,6-N-acetilglukozaminiltransferaza, GnTV) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:6-(2-(N-acetil-beta-D-glukozaminil)-alfa-D-manozil)-glikoprotein 6-beta-N-acetil-D-glukozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-D-glukozamin + 6-(2-[N-acetil-beta-D-glukozaminil]-alfa-D-manozil)-beta-D-manozil-R UDP + 6-(2,6-bis[N-acetil-beta-D-glukozaminil]-alfa-D-manozil)-beta-D-manozil-R
R označava ostatak N-vezanog oligosaharida u glikoproteinskom akceptoru.
Reference[уреди | уреди извор]
- ^ Cummings, R.D., Trowbridge, I.S. and Kornfeld, S. (1982). „A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: α-D-mannoside β1,6 N-acetylglucosaminyltransferase”. J. Biol. Chem. 257: 13421—13427. PMID 6216250.
- ^ Hindsgaul, O., Tahir, S.H., Srivastava, O.P. and Pierce, M. (1988). „The trisaccharide β-D-GlcpNAc-(1→2)-α-D-Manp-(1→6)-β-D-Manp, as its 8-methoxycarbonyloctyl glycoside, is an acceptor selective for N-acetylglucosaminyltransferase V”. Carbohydr. Res. 173: 263—272. PMID 2834054.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Alpha-1,6-mannosyl-glycoprotein+6-beta-N-acetylglucosaminyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
