OR1D2

Olfaktorni receptor, familija 1, potfamilija D, član 2
Olfaktorni receptor, familija 1, potfamilija D, član 2
Identifikatori
Simboli	OR1D2; OLFR1; OR17-4
Vanjski ID	OMIM: 164342 MGI: 3030246 HomoloGene: 37634 GeneCards: OR1D2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora; • aktivnost olfaktornog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa membranom;
Biološki proces	• respons na stimulus;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	4991
Ensembl	ENSG00000184166
UniProt	P34982
RefSeq (mRNA)	NM_002548.2
RefSeq (protein)	NP_002539.2
Lokacija (UCSC)	Chr 17:; 3 - 3 Mb
PubMed pretraga	[1]

Olfaktorni receptor 1D1 je protein koji je kod ljudi kodiran OR1D1 genom.^[1]^[2]^[3]

Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.^[3]

Reference[уреди | уреди извор]

^ Parmentier M; Libert F; Schurmans S; Schiffmann S; Lefort A; Eggerickx D; Ledent C; Mollereau C; Gerard C; Perret J; et al. (1992). „Expression of members of the putative olfactory receptor gene family in mammalian germ cells”. Nature. 355 (6359): 453—5. PMID 1370859. doi:10.1038/355453a0.
^ Buck L, Axel R (1991). „A novel multigene family may encode odorant receptors: a molecular basis for odor recognition”. Cell. 65 (1): 175—87. PMID 1840504. doi:10.1016/0092-8674(91)90418-X.
^ ^а ^б „Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2”.

Literatura[уреди | уреди извор]

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Schurmans S; Muscatelli F; Miot F; et al. (1993). „The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13→p12 region of the human genome and reveals an MspI restriction fragment length polymorphism”. Cytogenet. Cell Genet. 63 (3): 200—4. PMID 8097991. doi:10.1159/000133534.
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