Poliprenol reduktaza
| Poliprenol reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.94 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Poliprenol reduktaza (EC 1.3.1.94, SRD5A3 (gen), DFG10 (gen)) je enzim sa sistematskim imenom ditrans,policis-dolihol:NADP+ 2,3-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ditrans,policis-dolihol + NADP+ ditrans,policis-poliprenol + NADPH + H+
Reakcija se odvija u reverznom smeru uz redukciju terminalne dvostruke veze pored alkoholne grupe. Ovaj enzim je inicijalno izolovan iz ljudskog fetalnog moždanog tkiva. On je prisutan kod svih eukariota. U sisarskim ćelijama doliholi su predominanto 18-21 izoprenskih jedinica dugi.
Reference[уреди | уреди извор]
- ^ Sagami, H., Kurisaki, A. and Ogura, K. (1993). „Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver”. J. Biol. Chem. 268: 10109—10113. PMID 8486680.
- ^ Cantagrel, V., Lefeber, D.J., Ng, B.G., Guan, Z., Silhavy, J.L., Bielas, S.L., Lehle, L., Hombauer, H., Adamowicz, M., Swiezewska, E., De Brouwer, A.P., Blumel, P., Sykut-Cegielska, J., Houliston, S., Swistun, D., Ali, B.R., Dobyns, W.B., Babovic-Vuksanovic, D., van Bokhoven, H., Wevers, R.A., Raetz, C.R., Freeze, H.H., Morava, E., Al-Gazali, L. and Gleeson, J.G. (2010). „SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder”. Cell. 142: 203—217. PMID 20637498.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Polyprenol+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
